Irreversible dopamine-.beta.-hydroxylase inhibitors

Details Irreversible dopamine-.beta.-hydroxylase inhibitors Irreversible dopamine-.beta.-hydroxylase inhibitors

1985-09-09

1988-07-26

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558406, 558408, 560 55, 568441, A01K 31275, C07C12180

Patent

active

047600896

ABSTRACT:
Potent, irreversible dopamine-.beta.-hydroxylase inhibitors having the Formula: ##STR1## which are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors or 2-cyano-2-phenethylamine, and methods of using these inhibitors or 2-cyano-2-phenethylamine to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.

REFERENCES:
Taguchi et al., "Chem. Pharm. Bult.", vol. 29, No. 1 (1981), pp. 55-62.
Eiden et al., Arch. Pharmaz., 306, pp. 470-475 (1973).
Eiden et al., Arch. Pharmaz., 304, pp. 628-633 (1971).
Temulis et al., Chem. Abstracts, vol. 85: 123138p (1976).

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