Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-02-25
1998-07-14
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 911, 4352523, 4353201, 435325, 536 235, C12P 2100, C12P 1934, C12N 1563, C07H 2104
Patent
active
057802645
ABSTRACT:
This invention is directed to a novel protein of general significance to the cellular transport of nontransferrin bound iron. This heretofore unidentified protein, which is termed "stimulator of Fe (iron) transport" (SFT) protein, is essential to an alternative pathway of iron uptake. The cDNA encoding the SFT protein has been cloned and sequenced. The gene for the SFT protein has been mapped to chromosome 10, 17% of the distance from the centromere to the telomere of chromosome arm 10q, an area that corresponds to band 10q21. In addition, the amino acid structural identity of the SFT protein has been deduced, represented in a predicted transmembrane structure with a 6-transmembrane motif.
REFERENCES:
Gutierrez et al. Molecular mechanisms of iron transport. Critical Reviews in Eukaryotic Gene Expression vol. 6(1): 1-14 Feb. 1996.
Gutierrez Jesus
Wessling-Resnick Marianne
Degen Nancy
Sandals William
The President and Fellows of Harvard College
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