Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-03-22
1987-03-17
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514814, 546 6, C07D21369, A61K 31555
Patent
active
046507930
ABSTRACT:
Pharmaceutical compositions containing an iron complex of a 3-hydroxypyrid-2-one or 3-hydroxypyrid-4-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, are of value for the treatment of iron deficiency anemia.
REFERENCES:
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Howlin et al, Chemical Abstracts, 1982, vol. 97, No. 173875v and Howlin J. Chem. Soc. Dalton Trans., 1982, pp. 1433-1438.
Pitt and Gupta, Development of Iron Chelators for Clinical Use, Anderson and Hiller (Editors), 1975, p. 137, (Symposium Proceedings, Bethesda, Md., 9-22-75).
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Bartulin, Chemical Abstracts, vol. 97, 1982, p. 748, No. 92048a, Columbus, Ohio, USA; 122-124.
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Hider Robert C.
Kontoghiorghes George
Silver Jack
Stockham Michael A.
Berch Mark L.
National Research Development Corporation
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