Iron chelators and uses thereof

Details Iron chelators and uses thereof Iron chelators and uses thereof

2006-01-24

2006-01-24

Davis, Zinna Northington (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S332000, C514S336000, C514S342000, C546S255000, C546S283400, C546S309000

Reexamination Certificate

active

06989397

ABSTRACT:
The present invention provides 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) analogues suitable for use as an in vivo iron chelators, the PCIH analogue having Formula 1:wherein R1 is an aromatic or heterocyclic group and R2 is either H or OH; isomers thereof or salts thereof; pharmaceutical compositions containing the analogues; and uses of the analogues in the treatment of iron-overload diseases.

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