Iron catalyzed cross coupling reactions of aromatic compounds

Details Iron catalyzed cross coupling reactions of aromatic compounds Iron catalyzed cross coupling reactions of aromatic compounds

2006-04-11

2006-04-11

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S224000, C544S264000, C544S315000, C544S353000, C544S410000, C546S152000, C546S173000, C546S139000, C546S349000, C546S350000, C549S086000, C549S460000, C558S056000, C558S357000, C548S152000, C560S103000, C564S090000, C585S454000

Reexamination Certificate

active

07026478

ABSTRACT:
A process for the production of compounds Ar—R1by means of a cross-coupling reaction of an organometallic reagent R1-M with an aromatic or heteroaromatic substrate Ar—X catalyzed by one or several iron salts or iron complexes as catalysts or pre-catalysts, present homogeneously or heterogeneously in the reaction mixture. This new invention exhibits substantial advantages over established cross coupling methodology using palladium- or nickel complexes as the catalysts. Most notable aspects are the fact that (i) expensive and/or toxic nobel metal catalysts are replaced by cheap, stable, commercially available and toxicologically benign iron salts or iron complexes as the catalysts or pre-catalysts, (ii) commercially attractive aryl chlorides as well as various aryl sulfonates can be used as starting materials, (iii) the reaction can be performed under “ligand-free” conditons, and (iv) the reaction times are usually very short.

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