IRF-1 DNA expression inhibits growth of cells expressing c-myc o

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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4353201, C12N 1500

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active

056587740

ABSTRACT:
The present invention relates to a method of altering the phenotype of cells expressing an oncogene by expressing a nucleic acid encoding interferon regulatory factor 1 (IRF-1).

REFERENCES:
Tanaka et al., "Recognition DNA Sequences of Interferon Regulatory Factor 1 (IRF-1) and IRF-2, Regulators of Cell Growth and the Interferon System," Mol. Cell. Biol. 13 (8):4531-4538 (1993).
Tanaka, N., et al., "Cellular Commitment to Oncogene-Induced Transformation or Apoptosis is Dependent on the Transcription Factor IRF-1," Cell 77:829-839 (Jun. 17, 1994).
Cotten et al., "High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles," PNAS 89:6094-6098 (Jul. 1992).
Curiel et al., "Andenovirus enhancement of transferrin-polylysine-mediated gene delivery," PNAS 88:8850-8854 (Oct. 1991).
Curiel et al., "Gene Transfer to Respiratory Epithelial Cells via the Receptor-mediated Endocytosis Pathway," Am. J. Respir. Cell Mol. Biol. 6:247-252 (1992).
Curiel et al., "High-Efficiency Gene Transfer Mediated by Adenovirus Coupled to DNA-Polylysine Complexes," Human Gene Therapy 3:147-154 (1992).
Dhawan et al., "Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts," Science 254:1509-1512 (Dec. 6, 1991).
Eaton et al., "Construction and Characterization of an Active Factor VIII Variant Lacking the Central One-Third of the Molecule," Biochem. 25:8343-8347 (Dec. 30, 1986).
Harada et al., "Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2," Science 259:971-974 (Feb. 12, 1993).
Luthman & Magnusson, "High efficiency polyoma DNA transfection of chloroquine treated cells," Nucl. Acids Res. 11:1295-1308 (1983).
Maruyama et al., "Sequence of cDNA coding for human IRF-1," Nucl. Acids Res. 17:3292 (1989).
Miyamoto et al., "Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That Specifically Binds to IFN-.beta. Gene Regulatory Elements," Cell 54:903-913 (Sep. 9, 1988).
Morgan & Anderson, "Human Gene Therapy," Annu. Rev. Biochem. 62:191-217 (1993).
Nakabeppu et al., "Proliferative Activiation of Quienscent Rat-1A Cells by .DELTA.FosB," Mol. Cell. Biol. 13:4157-4166 (Jul. 1993).
Ponder et al., "Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation," PNAS 88:1217-1221 (Feb. 1991).
Roemer & Friedmann, "Concepts and strategies for human gene therapy," Eur. J. Biochem. 208:211-225 (1992).
Shiroki et al., "Neoplastic Transformation of Rat 3Y1 Cells by a Transcriptionally Activated Human c-myc Gene and Stabilization of p53 Cellular Tumor Antigen in the Trandformed Cells," Mol. Cell. Biol. 6:4379-4386 (Dec. 1986).
Wagner et al., "Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes" PNAS 89:6099-6103 (Jul. 1992).
Wagner et al., "DNA-Binding Transferrin Conjugates as Functional Gene-Delivery Agents: Synthesis by Linkage of Polylysine or Ethidium Homodimer to the Transferrin Carbonydrate Moiety," Bioconjugate Chem. 2:226-231 (1991).
Wagner et al., "Transferrin-polycation-DNA complexes: The effect of polycations on the structure of the complex and DNA delivery to cells," PNAS 88:4255-4259 (May 1991).
Willman et al., "Deletion of IRF-1, Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia," Science 259:968-971 (Feb. 12, 1993).
Zatloukal et al., "Transferrinfection: A Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells," Ann. New York Acad. Sci. 660:136-153 (1992).

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