Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1999-05-13
2000-12-26
Clark, Deborah J. R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 14, 800 21, 800 25, A01K 67027, C12N 1500
Patent
active
061662895
ABSTRACT:
A transgenic animal with alterations in an IRAK gene is prepared by introduction of an altered IRAK gene into a host animal. The resulting transgenic animals do not produce functional IRAK molecules. Cells and cell lines derived from these animals also contain the altered IRAK gene.
REFERENCES:
Palmiter et al. Science, vol. 222, p. 809-814, Nov. 1983.
Pursel et al., J. Reprod. Fert. Suppl. vol. 40, p. 235-245, 1990.
Wu et al., "New Strategies for Gene Knockout" in Methods in Gene Technology, CRC press, Inc. Boca Raton, Florida USA, p. 339-365, May 3, 1997.
Trofimova et al., Journal of Biological Chemistry, vol. 271 (30), p. 17609-17612, 1996.
Centanni et al., Mammalian Genome, vol. 9, p. 340-341, Apr. 1998.
Akira, Shizuo; Kishimoto, Tadamitsu. IL-6 and NF-IL6 in Acute-Phase Response and Viral Infection. Immunological Reviews. No. 127, 1992.
Baldwin Jr., Alberts S. The NF- B and I B Proteins: New discoveries and Insights. Annu. Rev. Immunol., 14:649-81, 1996.
Bankers-Fulbright, Jennifer L.; Kalli, Kimberly R.; McKean, David J. Interleukin-1 Signal Transduction. Life Sciences, vol. 59, No. 2, pp. 61-83, 1996.
Belvin, Marcia P.; Anderson, Kathryn V. A Conserved Signaling Pathway: The Drosophila Toll-Dorsal Pathway. Annu. Rev. Cell Biol, 12:393-416, 1996.
Bird, Timothy A.; Kyriakis, John M.; Tyshler, Leanna; Gayle, Margit; Milne, Alison; Virca, G. Duke. Interleukin-1 Activates p54 Mitogen-activated Protein (MAP) Kinase/Stress-activated Protein Kinase by a Pathway That Is Independent of p21.sup.ras, Raf-1, and MAP Kinase Kinase. The Journal of Biological Chemistry, vol. 269, No. 50, Issue of Dec. 16, pp. 31836-31844, 1994.
Cao, Zhaodan; Henzel, William J.; Gao, Xiong. IRAK: A Kinase Associated with the Interleukin-1 Receptor. Science, vol. 271, Feb. 23, 1996.
Cao, Zhadon; Xiong, Jessie; Takeuchi, Masahiro; Kurama, Takeshi; Goeddel, David V. TRAF6 is a signal transducer for interleukin-1. Letters To Nature, vol. 383, Oct. 3, 1996.
Centanni, John M.; de Miguel, Maria; Gopalan, Ganesan; Gilbert, Debra J.; Copeland, Neal G.; Jenkins, Nancy A.; Donovan, Peter J. Interleukin-1 receptor-associated kinase gene Illrak maps to the mouse X Chromosome. Mammalian Genome 9, Brief Data Reports, pp. 340-341.
Croston, Glenn E.; Cao, Zhaodan, Goeddel, David V. NF-.kappa.B Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity. The Journal of Biological Chemistry, vol. 270, No. 28, Issue of Jul. 14, pp. 16514-16517, 1995.
Didonato, Joseph A.; Hayakawa, Makio; Rothwarf, David M.; Zandi, Ebrahim; Karin, Michael. A cytokine-responsive I.kappa.B kinase that activates the transcription factor NF-.kappa.B. Nature, 388, 548-554, 1997.
Dinarello, Charles A.; Biologic Basis for Interleukin-1 in Disease. The Journal of The American Society of Hematology, vol. 87, No. 6, Mar. 15, 1996.
Fung-Leung, Wai-Ping; Schilham, Marco W.; Rahemtulla, Amin; Kundig, Thomas M.; Vollenwieder, Maja; Potter, Julia; van Ewijk, Willem; Mak, Tak W. Cell, vol. 65, 443-449, May 3, 1991.
Glaccum, Moira B.; Stocking, Kim L.; Charrier, Keith; Smith, Jeffrey L.; Willis, Cindy R.; Maliszewski, Charles; Livingston, David J.; Peschon, Jacques J.; Morrissey, Philip J. Phenotypic and Functional Characterization of Mice That Lack the Type I Receptor for IL-1. The Journal of Immunology, 159:3364-3371, 1997.
Huang, Jianing; Gao, Xiong; Li, Shyun; Cao, Zhaodan. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Pro. Natl. Acad. Sci. USA, vol. 94, pp. 12829-12832, Nov. 1997.
Kanakaraj, Palanisamy; Duckworth, Brian; Azzoni, Livio; Kamoun, Malek; Cantley, Lewis C.; Perussia, Bice. J. Exp. Med., vol. 179, 551-558, Feb. 1994.
Korherr, Christian; Hofmeister, Robert; Wesche, Holger; Falk, Werner. A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling. Eur. J. Immunol., 27:262-267, 1997.
Labow, Mark; Shuster, David; Zetterstrom, Maria; Nunes, Perla; Terry, Robert; Cullinan, Emily B.; Bartfai, Tamas; Solorzano, Carmen; Moldawer, Lyle L.; Chizzonite, Richard; McIntyre, Kim W. Absence of IL-1 Signaling and Reduced Inflammatory Response in IL-1 Type I Receptor-Deficient Mice. The Journal of Immunology, 159:2452-2461, 1997.
Lemaitre, Bruno; Nicholas, Emmanuelle; Michaut, Lydia; Reichhart, Jean-Marc; Hoffman, Jules A. The Dorsoventral Regulatory Gene Cassette spatzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults. Cell, vol. 86, 973-983, Sep. 20, 1996.
Leon, Lisa R.; Conn, Carole A.; Glaccum, Moira; Kluger, Matthew J. IL-1 type I receptor mediates acute phase response to turpentine but not lipopolysaccharide, in mice. The American Physiological Society, 1996.
Malinin, Nikolal L.; Boldin, Mark P.; Kovalenko, Andrel V.; Wallach, David. MAP3K-related kinase Involved in NF-.kappa.B Induction by TNF, CD95 and IL-1. Letters to Nature, vol. 385, Feb. 6, 1997.
Mercurio, Frank; Zhu, Hengyi; Murray, Brion W.; Shevchenko, Andrej; Bennett, Brydon L.; Li, Jian wu; Young, David B.; Barbosa, Miguel; Mann, Matthias. IKK-1 And IKK-2; Cytokine-Activated I.kappa.B Kinases Essential for NF-.kappa.B Activation. Science, vol. 278, Oct. 31, 1997.
Muzio, Marta; Ni, Jian; Feng, Ping; Dixit, Vishva M. IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling. Science, vol. 278, Nov. 28, 1997.
Natoli, Gioacchino; Costanzo, Antonio; Moretti, Francesca; Fulco, Marcella; Balsano, Clara; Levrero, Massimo. Tumor Necrosis Factor (TNF) Receptor 1 Signaling Downstream of TNF Receptor-associated Factor 2. The Journal of Biological Chemistry, vol. 272, No. 42, Issue of Oct. 17, pp. 26079-26082, 1997.
Osborn, Laurelee; Kunkel, Steven; Nabel, Gary J. Tumor necrosis factor .alpha. and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor .kappa.B. Proc. Natl. Acad. Sci. USA, vol. 86, pp. 2336-2340, Apr. 1989.
Pulverer, Bernd J.; Kyriakis, John M.; Avruch, Joseph; Nikolakaki, Eleni; Woodgett, James R. Phosphorylation of c-jun mediated by MAP kinases. Letters to Nature, vol. 353, Oct. 17, 1991.
Raingeaud, Joel; Gupta, Shashi; Rogers, Jeffrey S.; Dickens, Martin; Han, Jiahuai; Ulevitch, Richard J.; Davis, Roger J. Pro-inflammatory Cytokines and Environmental Stress Cause p38. Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine. The Journal of Biological Chemistry, vol. 270, No. 13, Issue of Mar. 31, pp. 7420-7426, 1995.
Ridley, Simon H.; Sarsfield, Simon J.; Lee, John C.; Bigg, Heather F.; Cawston, Tim E.; Taylor, David J.; DeWitt, David L.; Saklatvala, Jeremy. Actions of IL-1 are Selectively Controlled by p38 Mitogen-Activated Protein Kinase. The Journal of Immunology, 158:3165-3173, 1997.
Shelton, Christopher A.; Wasserman, Steven A. pelle Encodes a Protein Kinase Required to Establish Dorsoventral Polarity in the Drosophila Embryo. Cell, vol. 72, 515-525, Feb. 26, 1993.
Song, Ho Yeong; Regnier, Catherine H.; Kirshning, Carsten J.; Goeddel, David V.; Rothe, Mike. Tumor necrosis factor (TNF)-mediated kinase cascades; Bifurcation of Nuclear Factor-.kappa.B and c-jun N-terminal kinase (JNK/SAPK) pathways as TNF receptor-associated factor 2. Proc. Natl. Acad. Sci. USA, vol. 94, pp. 9792-9796, Sep. 1997.
Su, Bing; Karin, Michael. Mitogen-activated protein kinase cascades and regulation of gene expression. Current Opinion in Immunology. 8:402-411, 1996.
Trofimova, Marina; Sprenkle, Amy B.; Green, Melissa; Sturgill, Thomas W.; Goebl, Mark G.; Harrington, Maureen A. Developmental and Tissue-specific Expression of Mouse Pelle-like Protein Kinase. The Journal of Biological Chemistry, vol. 271, No. 30, Issue of July 26, pp. 17609-17612, 1996.
Trotta, Rosanna; Kanakaraj, Palanisamy; Perussia, Bice. Fc.gamma.R-dependent Mitogen-activated Protein Kinase Activation in Leukocytes: A Common Signal Transduction Event Necessary for Expression of TNF-.alpha. and Early Activation Genes. J. Exp. Med., vol. 184, Sep. 1996.
Wesche, Holger; Korherr, Christian; Kracht, Michael; Falk, Werner; Resch, Klaus; Martin, Michael U. The Interleukin-1 Receptor Acces
Harris Crafford A.
Leung Wai-Ping
Peterson Per A.
Siekierka John J.
Chen Shin-Lin
Clark Deborah J. R.
Ortho-McNeil Pharmacueticals
Wallen John W.
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