IRAK-4: compositions and methods of use

Details IRAK-4: compositions and methods of use IRAK-4: compositions and methods of use

2007-06-26

2007-06-26

Allen, Marianne P. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069100, C435S183000

Reexamination Certificate

active

10990276

ABSTRACT:
The present invention provides nucleic acids and polypeptides for IRAK-4, a novel member of the IRAK family of protein kinases. Members of the IRAK family are indispensable signal transducer for members of the IL-1R/Toll family of transmembrane receptors, including IL-1 receptors, IL-18 receptors and LPS receptors. IRAK-4 sequences from human and mouse are provided, as are methods for identifying compounds useful in the treatment or prevention of inflammatory diseases.

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