Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1998-09-15
2000-11-14
Bianco, Patricia
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
607 75, 607111, A61N 130, A61N 140, A61F 700
Patent
active
061482315
ABSTRACT:
Non-reusable, medicament-dispensing applicator electrodes adapted for use with an iontophoresis device for facilitating delivery of medication across the cutaneous membrane into adjacent underlying tissues and blood vessels. The embodiments of the iontophoresis electrode include an open mesh having cells in the medicament dispensing portions of the electrode which retain a medicament in the form of liquid, gel or ointment. The cells are adapted to contain and iontophoretically dispense and deliver medicament formulations, which have been previously approved for therapeutic use by cognizant regulatory authorities obviating the need for reformulation. The medicament-dispensing electrodes are composite or unitary in construction and may be useful in the treatment of acne and also genital herpes simplex infection which produces cutaneous lesions, including lesions above and below the waist. The delivery electrode, when used in accordance with the medicated electrode and method described herein, demonstrated >90% treatment efficacy in clinical trials for the treatment of genital herpes. In a particularly preferred embodiment, the dispensing electrode is adapted to be worn similarly to a glove thereby enabling the user to tactily position the medicament delivery electrode to make contact with the area to be treated; receiving current for iontophoretic transdermal delivery of medicament from a wrist-worn current driver. The electrode may also comprise a portion of one or more fingers of a glove or a whole palm to cover a larger area for self treatment. A glove having a large electrode area can be driven by a single current or a multichannel source such as described in prior patents by the present inventor.
REFERENCES:
patent: 279524 (1883-06-01), Beaty
patent: 3163166 (1964-12-01), Brant et al.
patent: 3298368 (1967-01-01), Charos
patent: 4383529 (1983-05-01), Webster
patent: 4474570 (1984-10-01), Ariura et al.
patent: 4510939 (1985-04-01), Brenman et al.
patent: 4689039 (1987-08-01), Masaki
patent: 4702732 (1987-10-01), Powers et al.
patent: 4747819 (1988-05-01), Phipps et al.
patent: 4787888 (1988-11-01), Fox
patent: 4838273 (1989-06-01), Cartmell
patent: 4919648 (1990-04-01), Sibalis
patent: 4953565 (1990-09-01), Tachibana et al.
patent: 4979938 (1990-12-01), Stephen et al.
patent: 4997418 (1991-03-01), DeMartini
patent: 5042975 (1991-08-01), Chien et al.
patent: 5160316 (1992-11-01), Henley
patent: 5162042 (1992-11-01), Gyory et al.
patent: 5203768 (1993-04-01), Haak et al.
patent: 5250022 (1993-10-01), Chien et al.
patent: 5279543 (1994-01-01), Glikfeld et al.
patent: 5298017 (1994-03-01), Theeuwes et al.
patent: 5312326 (1994-05-01), Myers et al.
patent: 5314502 (1994-05-01), McNichols et al.
patent: 5331979 (1994-07-01), Henley
patent: 5362307 (1994-11-01), Guy et al.
patent: 5362308 (1994-11-01), Chien et al.
patent: 5395310 (1995-03-01), Untereker et al.
patent: 5415629 (1995-05-01), Henley
patent: 5421816 (1995-06-01), Lipkovker
patent: 5441936 (1995-08-01), Houghten et al.
patent: 5458569 (1995-10-01), Kirk, III et al.
patent: 5464387 (1995-11-01), Haak et al.
patent: 5466217 (1995-11-01), Myers et al.
patent: 5470349 (1995-11-01), Kleditsch et al.
patent: 5558632 (1996-09-01), Lloyd et al.
patent: 5562607 (1996-10-01), Gyory
patent: 5607691 (1997-03-01), Hale et al.
patent: 5618275 (1997-04-01), Bock
patent: 5658247 (1997-08-01), Henley
patent: 5667487 (1997-09-01), Henley
patent: 5676648 (1997-10-01), Henley
patent: 5697896 (1997-12-01), McNichols et al.
patent: 5700457 (1997-12-01), Dixon
patent: 5711761 (1998-01-01), Untereker et al.
patent: 5713846 (1998-02-01), Bernhard et al.
patent: 5722397 (1998-03-01), Eppstein
patent: 5725817 (1998-03-01), Milder
patent: 5788666 (1998-08-01), Atanasoska
patent: 5795321 (1998-08-01), McArthur et al.
patent: 5797867 (1998-08-01), Guerrara et al.
patent: 5830175 (1998-11-01), Flower
patent: 5840057 (1998-11-01), Aloisi
patent: 5879323 (1999-03-01), Henley
patent: 5908401 (1999-06-01), Henley
patent: 5919155 (1999-07-01), Lattin et al.
patent: 5961482 (1999-10-01), Chien et al.
"Iontophoretic Treatment of Oral Herpes," Henley et al.; Laryngoscope, vol. 94, No. 1, pp. 118-121, Jan. 1984.
"Iontophoretic Application of Idoxuridine for Recurrent Herpes Labialis: Report of Preliminary Chemical Trials," Gangarosa et al.; Meth. And Find. Exptl. Clin. Pharmacol. 1(2), pp. 105-109 (1979).
"Iontophoresis of Vidarabine Monophosphate for Herpes Orolabialis," Gangarosa et al.; The Journal of Infectious Diseases, vol. 154, No. 6, pp. 930-934, Dec. 1986.
"The Natural History of Recurrent Herpes Simplex Labialis," Spruance et al.; The New England Journal of Medicine, vol. 297, No. 2, pp. 69-75, Jul. 14, 1977.
"Infection with Herpes-Simplex Viruses 1 and 2," Nahmias et al.; The New England Journal of Medicine, pp. 667-674, Sep. 27, 1973.
"Anesthesia of the Human Tympanic Membrane by Iontophoresis of a Local Anesthetic," Comeau et al.; The Laryngoscope, 88:1978, pp. 277-285.
"Iontophoretic Application of Drugs," Waud, J. Appl. Physiol. 23(1), 1967, pp. 128-130.
"Antibiotic Iontophoresis in the Treatment of Ear Chondritis," LaForest et al., Physical Therapy, vol. 58, No. 1, Jan. 1978, pp. 32-34.
"The Quantity and Distribution of Radiolabeled Dexamethasone Delivered to Tissue by Iontophoresis," Glass et al.; International Journal of Dermatology, vol. 19, Nov. 1980, pp. 519-525.
"Ocular Iontophoresis," Hill et al. Paper, Louisiana State University Medical Center, School of Medicine, New Orleans, Louisiana, pp. 331-354.
"Iontophoretic Application of Adenine Arabinoside Monophosphate to Herpes Simplex Virus Type 1-Infected Hairless Mouse Skin," Park et al.; Antimicrobial Agents and Chemotherapy, vol. 14, No. 4, Oct., 1978, pp. 605-608.
"Iontophoresis: Applications in Transdermal Medication Delivery," Costello et al.; Physical Therapy, vol. 75, No. 6, pp. 104/554-113/563, Jun. 1995.
Physical Enhancement of Dermatologic Drug Delivery: Iontophoresis and Phonophoresis,: Kassan et al.; Journal of the American Academy of Dermatology, Apr. 1996, pp. 657-666.
"Ionotophoresis and Herpes Labialis," Boxhall et al.; The Medical Journal of Australia, May 26, 1984, pp. 686-687.
"A Method of Antibiotic Administration in the Burn Patient," Rapperport et al.; Plastic and Reconstructive Surgery, vol. 36, No. 5, pp. 547-552.
"Iontophoresis for Enhancing Penetration of Dermatologic and Antiviral Drugs," Gangarosa et al., Journal of Dermatology, vol. 22, No. 11, pp. 865-875, Nov. 1995.
"Iontophoretic Treatment of Herpetic Whitlow," Gangarosa et al., Arch. Phys. Med. Rehabil., vol. 70, Apr. 1989.
"Iontophoretic Application of Antiviral Drugs," Gangarosa et al., Proceedings of an International Symposium held in Tokushima City, Japan, pp. 200-204, Jul. 27-30, 1981.
"Iontopheretic Application of Adenine Arabinoside Monophosphate for the Treatment of Herpes Simplex Virus Type 2 Skin Infections in Hairless Mice," Gangarosa, The Journal of Infectious Diseases, vol. 140, No. 6, p. 1014, Dec. 1979.
"Effect of Iontophoretic and Topical Application of Antiviral Agents in Treatment of Experimental HSV-1 Keratitis in Rabbits," Kwon et al., Investigative Ophthalmology & Visual Science, vol. 18, No. 9, pp. 984-988, Sep., 1979.
"Acyclovir and Vidarabine Monophosphate: Comparison of Iontophoretic and Intravenous Administration for the Treatment of HSV-1 Stromal Keratitis," Hill et al., The American Journal of Medicine, Acyclovir Symposium, pp. 300-304.
"Thymine Arabinoside (Ara-T) Topical and Iontophoretic Applications for Herpes Simplex Virus Type 1 and Type 2 Skin Infections in Hairless Mice," Hill et al., Meth. and Find. Exptl. Clin. Pharmacol. 6(1), pp. 17-20, 1984.
"Iontophoresis Enhances the Transport of Acyclovir Through Nude Mouse Skin by Electrorepulsion and Electroosmosis," Volpato et al., Pharmaceutical Research, vol. 12, No. 11, pp. 1623-1627, 1995.
"Early Application of Topical 15% Idoxuridine in Dimethyl Sulfoxide Shortens the Course of Herpes Simplex Labialis: A Multicenter Placebo-Controlled Trial," Spruance et al., The Journal of Infectious Diseases, 1990; 161; pp. 191-19
Bianco Patricia
Biophoretic Therapeutic Systems, LLC
LandOfFree
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