Iontophoretic devices

Details Iontophoretic devices Iontophoretic devices

2005-02-22

2005-02-22

Page, Thurman K. (Department: 1616)

Surgery

Means for introducing or removing material from body for...

C604S020000

Reexamination Certificate

active

06858018

ABSTRACT:
Iontophoretic devices for the delivery of N-phenyl-N-(4-piperidinyl)amide esters are provided. The N-phenyl-N-(4-piperidinyl)amide esters are compounds of the 1. A reservoir comprising a matrix material and, distributed in said matrix material, a pharmaceutically acceptable amount of at least one compound selected from compounds of the formula (I)wherein:X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl;Ar is a member selected from the group consisting of phenyl, and mono-, di- and tri-substituted phenyl, wherein each substituent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl;R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl,;R1is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl; andR2is a member selected from the group consisting of hydrogen and methyl; and the optically active and cis-trans isomers thereof, and the acid addition salts, of said compounds and isomers.

REFERENCES:
patent: 4141359 (1979-02-01), Jacobsen et al.
patent: 4588580 (1986-05-01), Gale et al.
patent: 4593053 (1986-06-01), Jevne et al.
patent: 5006108 (1991-04-01), LaPrade
patent: 5019583 (1991-05-01), Feldman et al.
patent: 5047007 (1991-09-01), McNichols et al.
patent: 5080546 (1992-01-01), Purvin et al.
patent: 5135479 (1992-08-01), Sibalis et al.
patent: 5143071 (1992-09-01), Keusch et al.
patent: 5169382 (1992-12-01), Theeuwes et al.
patent: 5203768 (1993-04-01), Haak et al.
patent: 5224927 (1993-07-01), Tapper
patent: 5224928 (1993-07-01), Sibalis et al.
patent: 5232438 (1993-08-01), Theeuwes et al.
patent: 5246418 (1993-09-01), Haynes et al.
patent: 5254081 (1993-10-01), Maurer et al.
patent: 5320597 (1994-06-01), Sage, Jr. et al.
patent: 5358483 (1994-10-01), Sibalis
patent: 5688232 (1997-11-01), Flower
patent: 5693024 (1997-12-01), Flower
patent: 5738647 (1998-04-01), Bernhard et al.
patent: 5882677 (1999-03-01), Kupperblatt
patent: 5910301 (1999-06-01), Farr et al.
patent: 0 904 779 (1999-03-01), None
patent: 2 239 803 (1991-07-01), None
patent: WO 9639224 (1996-12-01), None
patent: WO 9733645 (1997-09-01), None
patent: WO 9826760 (1998-06-01), None
Southam et al., Device for Transdermal Administration of Supentanil by Electrotransport, Neth. Appl., 1997.*
Suneel K. Gupta et al., Effect of Current Density on Pharmacokinetics Following Continuous or Intermittent Output from a Fentanyl Electrotransport System,Journal of Pharmaceutical Sciences, vol. 87, No. 8, Aug. 1998, pp. 976-981 (published on Web Jun. 13, 1998), American Chemical Society and American Pharmaceutical Association.
Hartmut Bürkle et al., Remifentanil: A Novel, Short-Acting μ-Opioid,Anesthesia and Analgesia, 83: pp. 646-651, (1996), International Anesthesia Research Society.
Sanjay S. Patel et al., Remfentanil,Drugs, Sep. 1996; 52 (3): pp. 417-427, (1996) Adis International Limited.
Hartmut Buerkle et al, Continuous Intrathecal Administration of Shortlasting μ Opiods Remifentanil and Alfentanil in the Rat,Anesthesiology, 84: pp. 926-935, (1996), American Society of Anesthesiologists, Inc., Lippencott-Raven Publishers.
Sophie Thysman et al., Transdermal iontophoresis of fentanlyl: delivery and mechanistic analysis,International Journal of Pharmaceutics, 101: pp. 105-113 (1994), Elseverier Science Publishers B.V.
Sophie Thysman et al., In Vivo Iontophoresis of Fentanyl and Sufentanil in Rats: Pharmacokinetics and Acute Antinociceptive Effects,Anesthesia and Analgesia, 77: pp. 61-66 (1993), International Anesthesia Research Society.
Véronique Préat et al., Transdermal iontophoretic delivery of sufentanil,International Journal of Pharmaceutics, 96: pp. 189-196 (1993), Elsevier Science Publishers B.V.
Geoffrey K. Gourlay et al., The transdermal administration of fentanyl in the treatment of postoperative pain: pharmacokinetics and pharmacodynamic effects,Pain, 37: pp. 193-202 (1989), Elsevier.
P.S. Sebel et al., Transdermal Absorption of Fentanyl and Sufentanil in Man,European Journal of Clinical Pharmacology, 32: pp. 529-531 (1987), Springer-Verlag.
Paul A. Janssen, The Development Of New Synthetic Narcotics,Opioids in Anesthesia, pp. 37-44 (Estafanous, F.G., ed.) Butterworth Publishers (1984).
L.E. Mather, Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives,Clinical Pharmacokinetics, 8: pp. 422-446 (1983), ADIS Press Austalasia Pty Ltd.

Affiliated with

Also associated with

Rating

Iontophoretic devices does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Iontophoretic devices, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Iontophoretic devices will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3453292