Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1996-10-30
1998-11-17
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 41, 264 43, A61K 9137
Patent
active
058372822
ABSTRACT:
Novel methods are provided for loading a weakly basic drug into liposomes utilizing an electoneutral transport system. In these methods, ionophores are utilized with liposomes having a metal ion gradient to facilitate the exchange of metal ions for protons. The transported metal ion will, in some embodiments, be complexed with a chelating agent which is present in the external media.
REFERENCES:
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4560665 (1985-12-01), Nakae et al.
patent: 4880635 (1989-11-01), Janoff
patent: 5077056 (1991-12-01), Bally et al.
patent: 5088499 (1992-02-01), Unger et al.
patent: 5169637 (1992-12-01), Lenk et al.
patent: 5192549 (1993-03-01), Barenolz et al.
patent: 5316771 (1994-05-01), Barenholz et al.
patent: 5352435 (1994-10-01), Unger et al.
patent: 5525232 (1996-06-01), Veiro
patent: 5578320 (1996-11-01), Janoff
patent: 5593688 (1997-01-01), Balderschwieler
Chonn et al., Current Opinion in Biotechnology 6:698-708 (1995).
Boman et al., Liposomes in Biomedical Applications, Shek, ed., Harwood Academic Publishers, Singapore, pp. 85-103 (1995).
Hope et al., Liposomes in Biomedical Applications Shek, ed., Harwood Academic Publishers, Singapore, pp. 121-134 (1995).
Mayer, et al., Cancer Res. 49:5922-5930 (1989).
Mayer, et al., J. Liposome Res. 1:463-480 (1990).
Boman, et al., Biochim. Biophys. Acta 1152:253-258 (1993).
Boman, et al., Cancer Res. 54:2830-2833 (1994).
Boman, et al., J. Liposome Research, 5:523-541 (1995).
Webb, et al., Briti. J. Cancer, 72:896-904 (1995).
Pressman, B.C., Ann. Rev. Biochem., 45:501-530 (1976).
Veiro, J.A. and Cullis, P.R., A Novel for the Efficient Entrapment of Ca.sup.2+ in Large Unilamellar Vesicles, Biochim. Biophys. Acta 1025, 109-115 (1990).
Chakrabarti, et al., Generation and Characterization of Iron and Barium Loaded Liposomes. Biochim. Biophys. Acta 1108, 233-239 (1992).
Wheeler et al., Ionophore-mediated Loading of Ca.sup.2+ into Large Unilamellar Vesicles in Response to Transmembrane pH Gradients. Molecular Membrane Biology, 11, 151-157 (1994).
Madden et al., The Accumulation of Drugs with Large Unilamellar Vesicles Exhibiting a Proton Gradient: a survey. Chem. Phys. Lipids 53, 37-46 (1190).
Erdahl, et al., Effect of pH Conditions on Ca.sup.2+ Transport Catalyzed by Ionophores A23187, 4-BrA23187, and Ionomycin Suggest Problems with Common Applications of these Compounds in Biological Systems. Biophys. J. 69, 2350-2363 (1995).
Waldeck, et al., .sup.23 Na-nuclear Magnetic resonance Study of Ionophore-mediated Cation Exchange Between Two populations of Vesicles, Biophys. J. 64, 1445-1455 (1993).
Kimmich et al., Biochem J., 168 (1), pp. 81-99, (Oct. 5, 1977).
Vuilleumier P. et al., Biochim Biophys Acta, 467(1) pp. 12-19, (May 16, 1977).
Deamer et al., The Response of Fluorescent Amines to pH Gradients Across Liposome Membranes, Biochim Biophys Acta, 274, 323-335 (1972).
Erdahl, et al. Biophys J., 66:1678-1693 (1994).
Leenhouts, et al., "New Procedures for the Loading of Doxorubicin Into Liposomes," FASEB Journal, vol. 11, No. 9, p. A1430 (1997).
Boman Nancy
Cullis Pieter R.
Fenske David B.
Leenhouts Johanna M.
Maurer Elisabeth
Kishore Gollamudi S.
University of British Columbia
LandOfFree
Ionophore-mediated liposome loading does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ionophore-mediated liposome loading, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ionophore-mediated liposome loading will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-881657