Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1997-03-03
1998-10-27
Anderson, Bruce
Radiant energy
Ionic separation or analysis
With sample supply means
250282, B01D 5944, H01J 4900
Patent
active
058280626
ABSTRACT:
An electrospray (ES) apparatus provides efficient reagent addition and improved ionization of an analyte aerosol at high flow rates by combining an ionized reagent aerosol with the analyte aerosol, thereby producing a superior ionized analyte aerosol for mass spectronomy (MS) implementations. The ES apparatus separately receives a reagent and a flow stream comprising analyte. The ES apparatus nebulizes the reagent and flow stream into aerosols, ionizes the reagent aerosol, combines the aerosols into an ionized analyte aerosol, and outputs the ionized analyte aerosol towards a mass spectrometer. The ionized analyte aerosol is formed at high flow rates and with effective reagent mixing, thereby minimizing flow stream aberrations and substantially improving signal sensitivity and selectivity in the mass spectrometer. Contact, mixing, and charge transfer between analyte and reagent particles is positively impacted in an aerosol format, thereby improving reagent mixing efficiency and producing a suitably ionized analyte aerosol at high flow rate. A plurality of nebulizers are used to provide the analyte and ionized reagent aerosols at high flow rate.
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Jarrell Joseph A.
Tomany Michael J.
Anderson Bruce
Janiuk Anthony J.
Michaelis Brian L.
Waters Investments Limited
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