Ionization by droplet impact

Details Ionization by droplet impact Ionization by droplet impact

2005-11-01

2008-12-16

Wells, Nikita (Department: 2881)

Radiant energy

Ion generation

Field ionization type

C250S424000, C250S288000, C250S281000, C250S282000

Reexamination Certificate

active

07465940

ABSTRACT:
The invention relates to methods and instruments for ionizing analyte molecules, preferably biomolecules, which are dissolved in liquids or firmly adsorbed on surfaces. Liquids are nebulized at atmospheric pressure by electrospraying. Highly charged microdroplets, which enter the vacuum of the mass spectrometer through the inlet capillary, strike an impact plate when energy is fed in. The repulsive Coulomb force of the charges, the absorption of additional thermal energy and/or the conversion of their kinetic energy into thermal energy cause the microdroplets to burst and evaporate. Analyte molecules which are located in the nebulized liquid or on the impact plate are released in charged form and can be fed to the mass spectrometer for analysis by the extraction and collection effect of an ion funnel operated with RF and DC voltages.

REFERENCES:
patent: 35413 (1862-05-01), Sawyer
patent: 4531056 (1985-07-01), Labowsky et al.
patent: 4542293 (1985-09-01), Fenn et al.
patent: 5481107 (1996-01-01), Takada et al.
patent: 5504329 (1996-04-01), Mann et al.
patent: 5570988 (1996-11-01), Gallaway et al.
patent: 5572035 (1996-11-01), Franzen
patent: 5756994 (1998-05-01), Bajic
patent: 5818041 (1998-10-01), Mordehai et al.
patent: 6107628 (2000-08-01), Smith et al.
patent: 6204500 (2001-03-01), Whitehouse et al.
patent: 6583408 (2003-06-01), Smith et al.
patent: 6806466 (2004-10-01), Guevremont et al.
patent: 7196326 (2007-03-01), Franzen et al.
patent: 2004/0188605 (2004-09-01), Tang et al.
patent: 195 15 271 (1995-04-01), None
patent: WO 2005/083415 (2005-09-01), None
Aksyonov, et al., “Impact desolvation of electrosprayed microdroplets—a new ionization method for mass spectrometry of large biomolecules”, Rapid Communications in Mass Spectrometry, vol. 15, John Wiley & Sons, Ltd., pp. 2001-2006, 2001.
Mahoney, et el., “Formation of Multiply Charged Ions from Large Molecules Using Massive-cluster Impact”, Rapid Communications in Mass Spectrometry, vol. 8, John Wiley & Sons, Ltd., pp. 403-406, 1994.
Takäts, et el., “Mass Spectrometry Sampling under Ambient Conditions with Desorption Electrospray Ionization”, Science, vol. 306, pp. 471-473, 2004.
Mahoney, et al., “Surface cleaning using energetic microcluster beams”, Solid State Technology, pp. 1-8, 1998.
Takats, et al., “Mass Spectrometry Sampling Under Ambient Conditions With Desorption Electrospray Ionization”, Science, Oct. 15, 2004, pp. 471-473, vol. 306.
Aksyonov, et al., “Impact Desolvation of Electrosprayed Microdroplets—A New ionization Method for Mass Spectrometry of Large Biomolecules”, Rapid Communications in Mass Spectrometry, 2001; vol. 15, pp. 2001-2006.
Mahoney, et al., “Formation of Multiply Charged Ions From Large Molecules Using Massive-Cluster Impact”, Rapid Communications in Mass Spectrometry, 1994, pp. 403-406, vol. 8.

Affiliated with

Also associated with

Rating

Ionization by droplet impact does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ionization by droplet impact, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ionization by droplet impact will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4044737