Ionic polymers and polymer-comprising substrates

Details Ionic polymers and polymer-comprising substrates Ionic polymers and polymer-comprising substrates

2007-10-30

2007-10-30

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

C436S528000, C436S532000, C436S524000, C436S085000, C436S823000, C435S007100

Reexamination Certificate

active

10851480

ABSTRACT:
An objective of the present invention is to provide ionic polymers that can provide for polymer-comprising substrates whose surfaces can stably and easily immobilize ligands such as sugar chains interacting with biological substances, in which the ligand portion exists stably even in water or buffer, and its detection capability does not decrease for a long period of time; and substrates comprising the polymers.The ionic polymer of this invention comprises two or more ionic functional groups (A) and two or more biointeracting groups represented by formula L-X-B-[wherein, L denotes a ligand capable of interacting with a biological substance, X denotes a spacer, and B denotes a binding group] as side chains covalently bound to a main chain polymer.

REFERENCES:
patent: 6231733 (2001-05-01), Nilsson et al.
patent: 6677164 (2004-01-01), Thoma et al.
patent: 2004/0077595 (2004-04-01), Cheng et al.
patent: 2005/0019573 (2005-01-01), Kai
patent: 2005/0180945 (2005-08-01), Chaikof et al.
Mammen et al., “Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors,”Angew. Chem. Int. Ed., 37:2754-2794 (1998).
Nishida et al., “A Facile Synthetic Approach to L- and P-Selectin Blockers via Copolymerization of Vinyl Monomers Constructing the Key Carbohydrate Modules of Sialyl LewisXMimics,”Biomacromolecules, 1:68-74 (2000).
Tsen et al., “Development and use of a multiplex PCR system for the rapid screening of heat labile toxin I, heat stable toxin II and shiga-lika toxin I and II genes ofEscherichia coliin water,”Journal of Applied Microbiology, 84:585-592 (1998).
Weeratna et al., “Detection and Production of Verotoxin 1 ofEscherichia coliO157:H7 in Food,”Applied and Environmental Microbiology, 57:10:2951-2955 (Oct. 1991).

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