Ionic molecular conjugates of N-acylated derivatives of poly(2-a

Details Ionic molecular conjugates of N-acylated derivatives of poly(2-a Ionic molecular conjugates of N-acylated derivatives of poly(2-a

1995-06-06

1997-09-09

Cain, Edward J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, A61K 3812

Patent

active

056657021

ABSTRACT:
A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.

REFERENCES:
patent: 4675189 (1987-06-01), Kent et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 5271945 (1993-12-01), Yoshioka et al.
Domard et al., "Preparation and Characterization of Fully Deacetylated Chitosan", Int. J. Biol. Macromol., 5:49-52, 1983.
Jameela et al., "Cross-Linked Chitosan Microspheres as Carriers for Prolonged Delivery of Macromolecular Drugs", J. Biomater. Sci. Polymer Edn., 6:621-632, 1994.
Mima et al., "Highly Deacetylated Chitosan and Its Properties", Journal of Applied Polymer Sciences, 28:1909-1917, 1983.
Song et al., "Pharmacokinetic Characteristics and Antitumor Activity of the N-Succinyl-chitosan-Mitomycin C . . . ", Biol. Pharm. Bull, 16:48-54, 1993.
Song et al., "Synthesis and Drug-Release Characteristics of the Conjugates of Mitomycin C with N-Succinyl-chitosan and Carboxymethyl-chitin", Chem. Pharm. Bull, 40:2822-2825, 1992.
Tokura et al., "Induction of Drug Specific Antibody and the Controlled Release of Drug by 6-0-Carboxymethyl-Chitin", Journal of Controlled Release, 28:235-241, 1994.
Watanabe et al., "6-0-Carboxymethyl-Chitin (CM-chitin) as a Drug Carrier", Chem. Pharm. Bull, 38:506-509, 1990.

Affiliated with

Also associated with

Rating

Ionic molecular conjugates of N-acylated derivatives of poly(2-a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ionic molecular conjugates of N-acylated derivatives of poly(2-a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ionic molecular conjugates of N-acylated derivatives of poly(2-a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-69973