Ionic molecular conjugates of N-acylated derivatives of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07005420

ABSTRACT:
A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.

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Jameela, et al., “Cross-linked Chitosan Microspheres as Carriers for Prolonged Delivery of Macromolecular Drugs,” 1994, J. Biomater. Sci. Polymer Edn., 6:621-632.
Mima, et al., “Highly Deacetylated Chitosan and Its Properties,” 1983, J. Applied Polymer Sci., 28:1909-1917.
Song, et al., “Synthesis and Drug-Release Characteristics of the Conjugates of Mitomycin C with N-Succinyl Chitosan and Carboxmethyl-chitin” 1992, Chem. Pharm. Bull., 40:2822-2825.
Song, et al., “Pharmacokinetic Characteristics and Antitumor Activity of the N-Succinyl-chitosan-Mitomycin Conjugate and the Carboxymethyl-chitin-Mitomycin C Conjugate,” 1993, Biol. Pharm. Bull., 16:48-54.
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Tokura, et al., “Induction of Drug Specific Antibody and the Controlled Release of Drug by 6-0-Carboxymethyl Chitin,” 1994, J. Controlled Release 28:235-241.
Watanabe, et al., “6.0-Carboxymethyl-Chitin (CM-chitin) as a Drug Carrier,” 1990, Chem. Pharm. Bull., 38:506-509.

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