Ionic molecular conjugates of biodegradable polyesters and bioac

Details Ionic molecular conjugates of biodegradable polyesters and bioac Ionic molecular conjugates of biodegradable polyesters and bioac

1997-06-02

1999-01-26

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

514 2, 5147723, 5147726, 514800, 514806, 514807, 514808, 514809, A61K 916, A61K 952, A61K 3702

Patent

active

058639853

ABSTRACT:
Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.

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Shah et al., "Poly (glycolic acid-co-DL-lactic acid): Diffusion or Degradation Controlled Drug Delivery?", Journal of Controlled Realeas, 18:261-270, 1992.

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