Ionic beads useful for controlled release and adsorption

Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Skin cosmetic coating

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424401, 424 7011, 424489, 514951, 264 43, 264 433, A61K 700, A61K 900

Patent

active

058717226

ABSTRACT:
Ionic compositions comprise an active ingredient absorbed within a network of internal pores defined by a plurality of polymeric particles. The particles are preferably crosslinked polymeric beads having a diameter in the range from about 5 to 100 microns and a surface charge density from about 0.1 to 10 meq/qm hydrogen ion capacity. The active ingredients are released from the ionic polymer beads over time when orally administered, applied to a keratinic material, typically human skin or hair or otherwise delivered to a target environment. The use of a cationic charge promotes adhesion of the beads to the keratinic material.

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patent: 5149543 (1992-09-01), Cohen
patent: 5407609 (1995-04-01), Tice
"Immobilization of enzymes with cationic crosslinked polymers", Chem. Abs., 113(1), 2575s (1990).
Hirokawa et al., "Phase Transitions of Positively Ionized Gels", Macromolecules, 18(12), 2782-2784 (1985).
"Production of Cationic, Highly Water-absorptive Resin", Patent Abstracts of Japan, 7(277) (C-199), Abstract of Japanese Patent Kokai No. Sho 58-154709 (1983).

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