Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;...
Patent
1998-01-22
1999-07-27
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
424422, 424 941, 435176, 435177, 435180, 435181, 436518, 436524, 436531, 436532, 530402, 530810, 530811, 530815, 530816, C12N 1100, G01N 33543, C07K 100, A61K 3843
Patent
active
059289163
ABSTRACT:
Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule having a negatively charged moiety is combined with a medical device surface having a positively charged guanidino moiety to form an ionic bond immobilizing a coating of the biomolecule on the surface. In another method, the medical device surface contains an amine moiety that is combined with a guanidino forming agent to form a positively charged guanidino moiety that is combined with the negatively charged moiety to form the ionic bond. In a further embodiment, the medical device surface contains a negatively charged moiety, and a biomolecule containing an amine moiety is combined with a guanidino forming agent to form a positively charged guanidino moiety that is combined with the negatively charged moiety to form the ionic bond.
REFERENCES:
patent: 3826678 (1974-07-01), Hoffman et al.
patent: 4521564 (1985-06-01), Solomon et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4613665 (1986-09-01), Larm
patent: 4642242 (1987-02-01), Solomon et al.
patent: 4720512 (1988-01-01), Hu et al.
patent: 4786556 (1988-11-01), Hu et al.
patent: 5032666 (1991-07-01), Hu et al.
patent: 5053048 (1991-10-01), Pinchuk
patent: 5077372 (1991-12-01), Hu et al.
patent: 5110909 (1992-05-01), Dellacherie et al.
patent: 5344455 (1994-09-01), Keogh et al.
patent: 5362852 (1994-11-01), Geoghegan
patent: 5429618 (1995-07-01), Keogh
R.G. Dickinson et al., "A New Sensitive and Specific Test for the Detection of Aldehydes: Formation of Commun., 1719-1720 (1970).
K.F. Geoghegan et al., "Site-Directed Conjugation of Nonpeptide Groups to Peptides and Proteins via Periodate Oxidation of a 2-Amino Alcohol. Application to Modification at N-Terminal Serine", Bioconjugate Chem., 3, 138-146 (1992).
A.S. Hoffman et al., ACovalent Binding of Biomolecules to Radiation-Grafted Hydrogels on Inert Polymer Surfaces,@Trans. Am. Soc. Artif. Intern. Organs, 18, 10-18 (1972).
S. Holmes et al., AAmination of Ultra-high Strength Polyethylene using Ammonia Plasma, @Composites Science and Technology, 38, 1-21 (1990).
Y. Ito et al., AMaterials for Enhancing Cell Adhesion by Immobilization of Cell-Adhesive Peptide,@J. Biomed. Mat. Res., 25, 1325-1337 (1991).
P.H. O.dbd.Farrell, AHigh Resolution Two-Dimensional Electrophoresis of Proteins,@J. Biol. Chem., 250, 4007-4021 (1975).
Medtronic Inc.
Naff David M.
Patton Harold R.
Woods Thomas F.
LandOfFree
Ionic attachment of biomolecules with a guanidino moiety to medi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ionic attachment of biomolecules with a guanidino moiety to medi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ionic attachment of biomolecules with a guanidino moiety to medi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-877745