Ion sensor for long term use in complex medium

Details Ion sensor for long term use in complex medium Ion sensor for long term use in complex medium

2008-02-21

2011-11-08

Marmor, II, Charles A (Department: 3735)

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

C600S345000

Reexamination Certificate

active

08055322

ABSTRACT:
Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.

REFERENCES:
patent: 3957613 (1976-05-01), Macur
patent: 4743352 (1988-05-01), Watkins-Pitchford
patent: 4891125 (1990-01-01), Schultz
patent: 4906348 (1990-03-01), Taichi et al.
patent: 4908117 (1990-03-01), Kinlen et al.
patent: 4927518 (1990-05-01), Tauber et al.
patent: 4980043 (1990-12-01), Tomita et al.
patent: 5034113 (1991-07-01), Iwamoto
patent: 5066383 (1991-11-01), Yamaguchi et al.
patent: 5139641 (1992-08-01), Neukum
patent: 5230786 (1993-07-01), Preidel
patent: 5234570 (1993-08-01), Taylor et al.
patent: 5334305 (1994-08-01), Okada et al.
patent: 5360529 (1994-11-01), Edwards et al.
patent: 5470453 (1995-11-01), Nipkow et al.
patent: 5951473 (1999-09-01), Sherry et al.
patent: 6419809 (2002-07-01), Suzuki et al.
patent: 6492179 (2002-12-01), Bar-Or et al.
patent: 6554982 (2003-04-01), Shin et al.
patent: 6616821 (2003-09-01), Broadley et al.
patent: 6663756 (2003-12-01), Lee et al.
patent: 7208121 (2007-04-01), Peper et al.
patent: 7621878 (2009-11-01), Ericson et al.
patent: 2004/0039265 (2004-02-01), Bardy
patent: 2004/0176672 (2004-09-01), Silver et al.
patent: 2005/0049492 (2005-03-01), Sweeney et al.
patent: 2006/0079740 (2006-04-01), Silver et al.
patent: 2006/0155177 (2006-07-01), Phillips et al.
patent: 2006/0191788 (2006-08-01), Wayment et al.
patent: 2009/0137890 (2009-05-01), Burnes et al.
patent: 00247535 (1992-09-01), None
patent: 00313657 (1994-05-01), None
patent: 00673506 (1994-09-01), None
patent: 00682247 (1995-11-01), None
patent: 01193495 (2002-04-01), None
patent: 01343002 (2003-09-01), None
patent: 61176846 (1986-12-01), None
patent: 9221960 (1992-12-01), None
patent: 9417399 (1994-08-01), None
patent: 9635116 (1996-07-01), None
patent: 0054039 (2000-09-01), None
Vogt S. et al., “Tierexperimentelle Studie Zum Aufbau Von Mikroelektroden Fuer Den Selektiven Nachweis Von Epikardialen Kaliumionenaktivitaeten. Experimental Study on Microelectrodes for the Selective Detection of Epicardial Potassium Ion Activities”, Biomedizinische Technik, Fachverlag Schiele Und Schoen Gmbh., 43(10), pp. 293-298 (1998).
Stiefel, Michael et al., “Cation dysfunction associated with cerebral ischemia followed by reperfusion: A comparison of microdialysis and ion-selective electrode methods”, Journal of Neurosurgery, 97(1), pp. 97-103 (2002).
Somps et al, “Electrochemical performance of an ion selective, polymeric membrane following chronic implantation in rat subcutaneous tissue,” Sensors and Actuators B, 35(1-3), pp. 22-227 (1996).
Linder, et al., “Ion-Selective Membranes with Low Plasticizer Content: Electroanalytical Characterization and Biocompatability Studies,” J. Biomed. Mat. Res., 28:591-601, (1994).
Simon et al., and D.M. Band, “Ion-selective electrodes and their clinical application in the continuous ion monitoring,” Annals New York Academy of Sciences, vol. 428, 279-285 (1984).
Cosofret et al., “Electroanalytical and surface characterization of encapsulated implantable membrane planar microsensors,” Analytica Chimica Acta, 314, pp. 1-11 (1995).
Dürselen et al., “Elimination of the asymmetry in neutral-carrier-based solvent polymeric membranes induced by proteins,” Anal. Chem., 60, pp. 1455-1458 (1988).
Lim et al., “Continuous intravascular monitoring of epinephrine-induced changes in plasma potassium,” Anesthesiology, 57(4), pp. 272-278 (1982).
Treasure, T. & Band, D. M., “A telemeter for ion selective catheter tipped electrodes,” J. Med. Eng. Technol., 1, pp. 271-273 (1977).
Cosofret et al., “Ion-selective microchemical sensors with reduced preconditioning time, membrane biostability studies and applications in blood analysis,” Analytical Letters, 27, pp. 3039-3063, (1994).

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