Ion selective monoelectrode complex

Details Ion selective monoelectrode complex Ion selective monoelectrode complex

2001-10-17

2004-07-27

Barr, Michael (Department: 1762)

Coating processes

Electrical product produced

Metal coating

C427S058000, C427S402000, C427S404000, C427S407100, C427S286000, C427S270000, C427S271000, C427S289000

Reexamination Certificate

active

06767578

ABSTRACT:

CROSS-REFERENCES TO RELATED APPLICATIONS
This application claims priority of Japanese Application No. 2000-316977 filed Oct. 17, 2000, the complete disclosure of which is hereby incorporated by reference.
FIELD OF THE INVENTION
The present invention relates to an ion selective monoelectrode complex and an ionic activity-measuring apparatus which is favorably employable for analysis of ionic components in liquid samples such as a whole blood sample, a serum sample, and a urine sample.
BACKGROUND OF THE INVENTION
An ionic activity-measuring apparatus utilizing an ion selective electrode is widely employed for analyzing ionic components in a liquid sample such as a whole blood sample or a serum sample.
U.S. Pat. No. 4,571,293 (which corresponds to EP 0 160 997 B1) discloses an ionic activity-measuring apparatus using an ion selective electrode which is illustrated in
FIG. 1
of the drawings attached to this specification.
In
FIG. 1
, the ionic activity-measuring apparatus comprises a non-electroconductive support
11
, a pair of electrodes each of which comprises a silver metal layer
12
a
,
12
b
and a silver halide layer
13
a
,
13
b
, a common electrolytic material layer
14
, a common ion selective membrane
15
, and a common non-electroconductive cover sheet
16
having a pair of openings
17
a
,
17
b
for receiving and keeping a sample solution and a reference solution, respectively, each opening being placed above each electrode unit, and having thereon an a bridge member
18
for electrically bridging the sample solution received in one opening
17
a
and the reference solution received in another opening
17
b
. Each of the silver metal layer
12
a
,
12
b
has an exposed surface
10
a
,
10
b
, respectively. By placing probes of a potentiometer
19
on these exposed silver metal surface
10
a
,
10
b
, the produced electric potential difference can be measured.
FIG. 2
illustrates an industrially employed process for preparing the ionic activity-measuring apparatus of FIG.
1
.
In industry, the ionic activity-measuring apparatus of
FIG. 1
is generally manufactured in a mass scale, by the steps of:
(1) preparing a longitudinal sheet composed of a non-electroconductive sheet
11
and a silver metal layer
12
deposited or laminated on the non-electroconductive sheet
11
;
(2) making a linear scratch
21
on the silver metal layer
12
under the condition that the scratch is extended in the longitudinal direction and reach the non-electroconductive sheet
11
, to divide the silver metal layer
12
into two silver metal portions
12
a
,
12
b
, and covering each silver metal portion
12
a
,
12
b
on its side areas with a polymer material layer
20
a
,
20
b
, leaving uncovered area in the form of a stripe (or belt) on the silver metal portion
12
a
,
12
b;
(3) halogenating the silver metal portion
12
a
,
12
b
in the uncovered areas to form silver halide layers
13
a
,
13
b
, respectively, on the surface of the silver metal portion in the uncovered area;
(4) forming an electrolytic material layer
14
on the scratch and the silver halide portions;
(5) peeling the polymer material layer
20
a
,
20
b
off from the silver metal layer to produce an exposed silver metal area
10
a
,
10
b
, and placing an ion selective membrane
15
on an electrolytic material layer
14
; and
(6) finally placing a non-electroconductive member
16
having two openings
17
a
,
17
b
on the ion selective membrane
15
and then placing a bridge
18
on the member
16
to connect the openings
12
a
,
17
b.
The above-described industrial method is advantageous for manufacturing a great number of ion selective electrodes in a mass scale.
The ion selective electrode can measure an ionic activity of H
+
, Li
+
, Na
+
, K
+
, Mg
2+
, Ca
2+
, Cl
−
, HCO
3
−
, or CO
3
2−
, by employing an appropriate ion selective membrane.
U.S. Pat. No. 4,789,435 describes an ion selective electrode assembly comprising plural ion selective electrodes for analyzing plural ionic components such as Na
+
, K
+
, and Cl
−
, simultaneously. In the assembly, one of plural ion selective electrodes has an ion selective membrane differing from that of other ion selective electrode in chemical composition.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide an ion selective electrode having a satisfactory analytical performance at a relatively low production cost.
The object of the invention also resides in providing a method of manufacturing ion selective electrodes having satisfactory analytical performance in a mass scale at a relatively low production cost.
The present invention resides in an ion selective monoelectrode complex (hereinafter referred to as “Type A” complex), on a common non-electroconductive support sheet, plural ion selective monoelectrodes each of which is composed of an electrode composite comprising, in order, a silver metal layer, a silver halide layer, an electrolytic material layer, and an ion selective membrane, and an electroconductive terminal which is electrically connected to the silver metal layer and which has an exposed surface, under the condition that the ion selective monoelectrodes are aligned, without electric contact with each other, along an imaginary line bridging the electrode composite and the electroconductive terminal
The above-mentioned ion selective electrode of Type A is preferably manufactured in a mass scale by a process comprising the steps of:
making two or more linear scratches on a longitudinal non-electroconductive sheet having thereon a silver metal layer under the condition that the scratches are extended in the longitudinal direction and reach the non-electroconductive sheet;
covering the silver metal layer with a polymer material layer in the form of a stripe on one side of each linear scratch, leaving uncovered area in the form of a stripe;
halogenating the silver metal layer in the uncovered area to form a silver halide layer on the surface of the silver metal layer in the uncovered area;
forming an electrolytic material layer on the polymer material layer and the silver halide layer;
peeling the polymer material layer off from the silver metal layer to remove the polymer material layer and the electrolytic material layer placed on the polymer material layer simultaneously;
placing an ion selective membrane on an electrolytic material layer formed on the silver halide layer; and
cutting thus processed longitudinal sheet in the direction traversing the longitudinal sheet to give a plurality of the ion selective monoelectrode complexes.
The ion selective electrode of Type A is also preferably manufactured in a mass scale by a process comprising the steps of:
covering a longitudinal non-electroconductive sheet having thereon a silver metal layer with two or more polymer material layers in the form of a stripe in the longitudinal direction, leaving uncovered area in the form of a stripe;
making one or more linear scratches on the silver metal layer in the vicinity of the polymer material layers under the condition that the scratches are extended in the longitudinal direction and reach the non-electroconductive sheet;
halogenating the silver metal layer in the uncovered area to form a silver halide layer on the surface of the silver metal layer in the uncovered area;
forming an electrolytic material layer on the polymer material layer and the silver halide layer;
peeling the polymer material layer off from the silver metal layer to remove the polymer material layer and the electrolytic material layer placed on the polymer material layer, simultaneously;
placing an ion selective membrane on an electrolytic material layer formed on the silver halide layer; and
cutting thus processed longitudinal sheet in the direction traversing the longitudinal sheet to give a plurality of the ion selective monoelectrode complexes.
The present invention also resides in an ionic activity measuring apparatus (of Type A) comprising a pair of the ion selective monoelectrode complex, which are

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