Ion-implanted protein-coated intralumenal implants

Details Ion-implanted protein-coated intralumenal implants Ion-implanted protein-coated intralumenal implants

1997-05-22

1999-04-06

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

A61F 206

Patent

active

058911928

ABSTRACT:
Ion-implanted protein-coated occlusion coils are described which have essentially the same dimensions as untreated coils and exhibit altered surface properties, e.g., thrombogenicity, endothelial cellular migration and adhesion, relative to untreated coils thus making them particularly useful in treating wide-necked brain aneurysms.

REFERENCES:
patent: 5152783 (1992-10-01), Suzuki et al.
patent: 5308704 (1994-05-01), Suzuki et al.
patent: 5690670 (1997-11-01), Davidson
Ahuja et al., "Platinum coil coatings to increase thrombogenicity: A preliminary study in rabbits" AJNR (Jul./Aug. 1993) 14:794-798.
Dawson et al., "Treatment of experimental aneurysms using collagen-coated microcoils" J. Neurosurgery (1995) 36(1):133-139.
Iwaki, M., "Formation of metal surface layers with high performance by ion implantation" Nucl. Inst. Meth. Phys. Res. B37/38 (1989) Elsevier Science Publishers, Amsterdam, pp. 661-666.
Murayama et al., "New surface modification of electrically detachable oil (GDC) by ion implantation into proteins" Kobunshi Gakkai Yokoshu (Polymer Preprints, Japan) (1996) 45(3):310. English translation enclosed.
Suzuki et al., "Cell adhesion control by ion implantation into extra-cellular matrix" Nucl. Instr. and Meth. in Phys. Res. B (1994) 91:588-592.
Suzuki et al., "Ion implantation into collagen for the subsrate of small diameter artificial grafts" Kobunshi Gakkai Yokoshu (Polymer Preprints, Japan) (1996) 45(3):310. English translation enclosed.

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