Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2011-02-15
2011-02-15
Kim, Robert (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S281000, C250S282000
Reexamination Certificate
active
07888635
ABSTRACT:
An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of ˜1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of ˜10,000,000 elementary charges, 4) ion ejection time of 40 to 200 μs, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.
REFERENCES:
patent: 5206506 (1993-04-01), Kirchner
patent: 2004/0094702 (2004-05-01), Clemmer
patent: 2005/0092911 (2005-05-01), Hoyes
patent: 2005/0258364 (2005-11-01), Whitehouse et al.
patent: 2006/0226353 (2006-10-01), Tang et al.
patent: 2008/0302958 (2008-12-01), Green
patent: 2009/0134321 (2009-05-01), Hoyes
patent: 2010/0065737 (2010-03-01), Bateman et al.
patent: 2010/0237237 (2010-09-01), Green et al.
Wyttenbach et al., Design of a new electrospray ion mobility mass spectrometer, International Journal of Mass Spectrometry, vol. 212, (2001), pp. 13-23.
Creaser et al., A Tandem Ion Trap/Ion Mobility Spectrometer, Anal. Chem, vol. 72, (2000), p. 2724-2729.
Eiceman et al., Review of Scientific Instruments, vol. 72, No. 9, Sep. 2001, pp. 3610-3621.
Hoaglund et al., An Ion Trap Interface for ESI-Ion Mobility Experiments, Anal. Chem, vol. 69, (1997), pp. 4156-4161.
Ibrahim et al., Ion-Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry, Anal. Chem, vol. 79, (2009), pp. 7845-7852.
Tang et al., High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces, Anal. Chem., vol. 77, (2005), pp. 3330-3339.
Shaffer et al., A Novel Ion Funnel for Focusing Ions at Elevated Pressure Using Electrospray Ionization Mass Spectrometry, Rapid Communication Mass Spectrometry, 1997, vol. 11, pp. 1813-1817.
Belov Mikhail E.
Clowers Biran H.
Ibrahim Yehia M.
Prior David C.
Smith Richard D.
Battelle (Memorial Institute)
Ippolito Rausch Nicole
Kim Robert
Matheson James D.
LandOfFree
Ion funnel ion trap and process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ion funnel ion trap and process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ion funnel ion trap and process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2635038