Ion fragmentation parameter selection systems and methods

Details Ion fragmentation parameter selection systems and methods Ion fragmentation parameter selection systems and methods

2007-06-19

2007-06-19

Nguyen, Kiet T. (Department: 2881)

Radiant energy

Ionic separation or analysis

Cyclically varying ion selecting field means

C250S281000, C250S282000

Reexamination Certificate

active

11317854

ABSTRACT:
In some embodiments, a tandem (MS/MS) mass spectrometry method includes selecting a collision-induced dissociation (CID) voltage amplitude and a q-parameter value for a quadrupole ion trap to optimize a daughter ion fragmentation process for a given parent ion mass-to-charge (m/z) ratio. The q and CID voltage values may be selected according to a look-up table and/or using approximate analytical expressions. The correspondence between m/z values and (q, CID) value pairs may be established by pre-measurement calibration. A fragmentation-optimized q value may be computed according to m/z, and a CID voltage value may be determined according to the computed q value. A user may also force q to another value, for example in order to facilitate trapping of a desired daughter ion mass range, and the controller computes a CID voltage value according to the forced q value.

REFERENCES:
patent: 6124591 (2000-09-01), Schwartz et al.
patent: 7102129 (2006-09-01), Schwartz
Article by March, Raymond E., entitled “An Introduction to Quadrupole Ion Trap Mass Spectrometry” published by Journal of Mass Spectrometry, vol. 32, 351-369 (1997).
Article by Nam, et al., entitled “GC-MS/MS Analysis of Benzo(a)pyrene by Ion Trap Tandem Mass Spectrometry”, published by Bull. Korean Chem. Soc. 2002, vol. 23, No. 8, pp. 1097-1102.

Affiliated with

Also associated with

Rating

Ion fragmentation parameter selection systems and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ion fragmentation parameter selection systems and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ion fragmentation parameter selection systems and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3876531