Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means
Reexamination Certificate
2007-06-19
2007-06-19
Nguyen, Kiet T. (Department: 2881)
Radiant energy
Ionic separation or analysis
Cyclically varying ion selecting field means
C250S281000, C250S282000
Reexamination Certificate
active
11317854
ABSTRACT:
In some embodiments, a tandem (MS/MS) mass spectrometry method includes selecting a collision-induced dissociation (CID) voltage amplitude and a q-parameter value for a quadrupole ion trap to optimize a daughter ion fragmentation process for a given parent ion mass-to-charge (m/z) ratio. The q and CID voltage values may be selected according to a look-up table and/or using approximate analytical expressions. The correspondence between m/z values and (q, CID) value pairs may be established by pre-measurement calibration. A fragmentation-optimized q value may be computed according to m/z, and a CID voltage value may be determined according to the computed q value. A user may also force q to another value, for example in order to facilitate trapping of a desired daughter ion mass range, and the controller computes a CID voltage value according to the forced q value.
REFERENCES:
patent: 6124591 (2000-09-01), Schwartz et al.
patent: 7102129 (2006-09-01), Schwartz
Article by March, Raymond E., entitled “An Introduction to Quadrupole Ion Trap Mass Spectrometry” published by Journal of Mass Spectrometry, vol. 32, 351-369 (1997).
Article by Nam, et al., entitled “GC-MS/MS Analysis of Benzo(a)pyrene by Ion Trap Tandem Mass Spectrometry”, published by Bull. Korean Chem. Soc. 2002, vol. 23, No. 8, pp. 1097-1102.
Specht August
Wells Gregory J.
Bella Fishman Andrei Popovici
Nguyen Kiet T.
Varian Inc.
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