Ion fragmentation in mass spectrometry

Details Ion fragmentation in mass spectrometry Ion fragmentation in mass spectrometry

2009-01-30

2010-06-15

Wells, Nikita (Department: 2881)

Radiant energy

Ionic separation or analysis

Ion beam pulsing means with detector synchronizing means

C250S281000, C250S282000, C250S288000, C250S292000, C250S42300F

Reexamination Certificate

active

07737396

ABSTRACT:
In a tandem mass spectrometer using a collision cell for ion fragmentation, the upper limit of the collision energy required for collision induced dissociation (CID) can be extended without reaching or going beyond the upper electrical discharge limit of the system components. The present teachings describe a method of lifting the potential energy of ions to a predetermined level sufficient for CID fragmentation while satisfying a discharge free condition. The present teaching also describes a method of lifting the potential energy of the fragment ions after CID fragmentation so that the product ions have sufficient energy for mass analysis.

REFERENCES:
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patent: 6512226 (2003-01-01), Loboda et al.
patent: 6992285 (2006-01-01), Cousins et al.
patent: 7227137 (2007-06-01), Londry et al.
patent: 7459693 (2008-12-01), Park et al.
patent: 7547878 (2009-06-01), Schultz et al.
patent: 7557344 (2009-07-01), Chernushevich et al.

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