Ion exchanger treatment of citrate-stabilized plasma

Details Ion exchanger treatment of citrate-stabilized plasma Ion exchanger treatment of citrate-stabilized plasma

1978-02-06

1979-10-09

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, A23J 106

Patent

active

041705904

ABSTRACT:
A citrate-stabilized blood plasma is frozen and thawed, the undissolved cryoprecipitate is separated and is rich in factor VIII protein. The residual liquid is treated with cation and anion exchangers, either sequentially or in admixture, to separate calcium and citrate ions therefrom. The residual plasma is then subjected to adsorption to remove a fraction which is eluted and precipitated, enriched in factors II, VII, IX and X. The liquid left from adsorption is subjected to further adsorption with silicic acid, leaving a storage-stable serum. The silicic acid is eluted to dissolve adsorbed fibrinogen which then is re-precipitated.

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patent: 3652530 (1972-03-01), Johnson et al.
patent: 3682881 (1972-08-01), Fekete et al.
patent: 3869436 (1975-03-01), Falksveden
patent: 3916026 (1975-10-01), Stephan
patent: 3920625 (1975-11-01), Andersson et al.
patent: 3973002 (1976-08-01), Hagan et al.
Laursen et al., Chemical Abstracts, vol. 67:50,325p (1967).
Reid et al., Ind. & Eng. Chem., vol. 43, No. 5 (1951), pp. 1074 and 1075.
Tullis et al., The New England Journal of Medicine, vol. 273, No. 13 (1965), pp. 667-674.

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