Chemistry of inorganic compounds – Treating mixture to obtain metal containing compound – Radioactive metal
Reexamination Certificate
2007-05-01
2007-05-01
Vanoy, Timothy C. (Department: 1754)
Chemistry of inorganic compounds
Treating mixture to obtain metal containing compound
Radioactive metal
C423S006000, C423S249000, C423S305000, C423SDIG018, C252S184000
Reexamination Certificate
active
10354929
ABSTRACT:
A bismuth-213 generator comprising an insoluble composition having the general formula Zr(Phosponate)x(HPO4)2−x.nH2O, wherein x is between 0 and 2; and n is the number of waters of hydration; and wherein cations of radioactive isotopes selected from radium, actinium and combinations thereof are immobilized on the composition. The value of x may be between about 0.2 and about 1. The phosphonate may be n-phosphonomethyl-miniodiacetic acid (PMIDA), wherein x may be between about 0.1 and about 1.9. The phosphonate may be one or more phosphonate having the formula:in-line-formulae description="In-line Formulae" end="lead"?H2O3P—(CH2)a—N—((CH2)bCO2H)—((CH2)cCO2H),in-line-formulae description="In-line Formulae" end="tail"?wherein a, b, and c are numbers from 1 to 3 that may or may not be equal. The value of x may also be between about 0.1 and 1.9.
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Dangshe Ma, Michael R. McDevitt, Ronald D. Finn,David A. Scheinberg; Breakthrough of225Ac and its radionuclide daughters from an225Ac/213Bi generator; development of new methods, quantitative characterization, and implications for clinical use; Applied Radiation and Isotopes 55 (2001) 667-678.
Clearfield Abraham
Dietz Mark L.
Sylvester Paul
Lynntech Inc.
Streets Jeffrey L.
Streets & Steele
The Texas A&M University System
U Chicago Argonne LLC
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