Ion-channel forming peptides

Details Ion-channel forming peptides Ion-channel forming peptides

1991-05-10

1993-08-24

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

24 amino acid residues in defined sequence

530326, 514 13, 514 12, 514 2, 514 21, 930190, 930DIG822, 930DIG821, 930DIG820, C07K 710

Patent

active

052390594

ABSTRACT:
A biologically active peptide which includes the following structure:

REFERENCES:
patent: 4810777 (1989-03-01), Zasloff et al.
patent: 4962277 (1990-10-01), Cuervo et al.
patent: 5073542 (1991-12-01), Zasloff
patent: 5114921 (1992-05-01), Zasloff
Li et al, FEBS Letters, vol. 231, No. 2, pp. 299-302.
Westerhoff et al, PNAS, vol. 86, pp. 6597-6601, (1989).
Moore et al, J. Biol. Chem., vol. 266(29), pp. 19851-19857 [Chem. Abs., vol. 115 (19), 205868d], (1991).
Berkowitz et al, Chem. Abs., vol. 115, (19), 198541m, (1991).
B. Christensen, et al., "Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes," Proc. Natl. Acad. Sci., vol. 85, pp. 5072-5076, Jul. 1988.
Merrifield, "Solid Phase Peptide Synthesis," Journal of the American Chemical Society, vol. 85, pp. 2149-2154 (1963).

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