Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-31
2009-11-10
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07615357
ABSTRACT:
A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
REFERENCES:
patent: 4072578 (1978-02-01), Cady et al.
patent: 4461304 (1984-07-01), Kuperstein
patent: 4514500 (1985-04-01), Giaever et al.
patent: 4628933 (1986-12-01), Michelson
patent: 4677989 (1987-07-01), Robblee
patent: 4695547 (1987-09-01), Hilliard et al.
patent: 4699881 (1987-10-01), Matschke
patent: 4801543 (1989-01-01), Arnold et al.
patent: 4969468 (1990-11-01), Byers et al.
patent: 4970154 (1990-11-01), Chang
patent: 5024223 (1991-06-01), Chow
patent: 5128257 (1992-07-01), Baer
patent: 5178161 (1993-01-01), Kovacs
patent: 5187096 (1993-02-01), Giaever et al.
patent: 5194133 (1993-03-01), Clark et al.
patent: 5405367 (1995-04-01), Schulman et al.
patent: 5422272 (1995-06-01), Papp et al.
patent: 5432086 (1995-07-01), Fränzl et al.
patent: 5439440 (1995-08-01), Hofmann
patent: 5545130 (1996-08-01), Hofmann et al.
patent: 5563067 (1996-10-01), Sugihara et al.
patent: 5571158 (1996-11-01), Bolz et al.
patent: 5643742 (1997-07-01), Malin et al.
patent: 5810725 (1998-09-01), Sugihara et al.
patent: 5855801 (1999-01-01), Lin et al.
patent: 5935155 (1999-08-01), Humayun et al.
patent: 5957958 (1999-09-01), Schulman et al.
patent: 5965452 (1999-10-01), Kovacs
patent: 5972694 (1999-10-01), Mathus
patent: 5981268 (1999-11-01), Kovacs et al.
patent: 6008038 (1999-12-01), Kröger et al.
patent: 6009347 (1999-12-01), Hofmann
patent: 6024702 (2000-02-01), Iversen
patent: 6031711 (2000-02-01), Tennent et al.
patent: 6038478 (2000-03-01), Yuen et al.
patent: 6046002 (2000-04-01), Davis et al.
patent: 6051422 (2000-04-01), Kovacs et al.
patent: 6063260 (2000-05-01), Olesen et al.
patent: 6099960 (2000-08-01), Tennent et al.
patent: 6205016 (2001-03-01), Niu
patent: 6352853 (2002-03-01), King et al.
patent: 6376233 (2002-04-01), Wolf et al.
patent: 6686193 (2004-02-01), Maher et al.
patent: 6969449 (2005-11-01), Maher et al.
patent: 7276206 (2007-10-01), Augustine et al.
patent: 0 594 282 (1994-04-01), None
patent: 1 067 378 (2001-01-01), None
patent: 96/41166 (1996-12-01), None
patent: WO97/05922 (1997-02-01), None
patent: WO 98/54294 (1998-12-01), None
patent: WO00/25121 (2000-05-01), None
patent: WO 00/34434 (2000-06-01), None
patent: WO00/68686 (2000-11-01), None
U.S. Appl. No. 09/804,457, filed Mar. 12, 2001, Maher et al.
U.S. Appl. No. 09/804,480, filed Mar. 12, 2001, Maher et al.
U.S. Appl. No. 10/620,312, filed Jul. 14, 2003, Maher et al.
U.S. Appl. No. 10/770,861, filed Feb. 2, 2004, Maher et al.
U.S. Appl. No. 10/771,283, filed Feb. 2, 2004, Maher et al.
Arndts, Oral Presentation Abstract, Second International Cell Analysis Products Users Meeting in Hilton Head Island, South Carolina, USA (Jun. 3-5, 1998).
Barr and Plonsey, Biophys. J. 61, 1164-1175 (1992).
Barr and Plonsey, IEEE 42, 1185-11911 (1995).
Brust-Mascher, I et al., “Calcium Waves Induced by Large Voltage Pulses in Fish Keratocytes”, Biophysical Journal, (1998) 75(4): 1669-1678.
Cartee and Plonsey, IEEE 39, 76-85 (1992).
Cartee and Plonsey, Med & Biol. Eng. & Comp. 30 389-398 (1992).
Denyer, J et al., “HTS Approaches to Voltage-Gated Ion Channel Drug Discovery Today”, (1998) 3(7): 323-332.
Eppich et al., Nature Biotech. 18, 882-887 (2000).
Giuliano, K.A., et al., “Fluorescent-protein biosensors: new tools for drug discovery”, Trends In Biotechnology, vol. 16, No. 3, pp. 135-140, (Mar. 1998).
González, J.E., et al., “Voltage sensing by fluorescence resonance energy transfer in single cells”, Biophysical Journal, vol. 69, No. 4, pp. 1272-1280, (Oct. 1995).
González, J.E., et al., “Cell-based assays and instrumentation for screening ion-channel targets”, Drug Discover Today, vol. 4, No. 9, pp. 431-439, (Sep. 1999).
Greenberg, et al. IEEE 46, 505-514 (1999).
Gross, et al. Biophys. J. 50, 339-348 (1986).
Jacobs et al., “Control of Action Potential-Induced Ca2=Signaling in the Soma of Hippocampal Neurons by Ca2+Release from Intracellular Stores”, (1997) Journal of Neuroscience 17(11):4129-4135.
Jentsch and Günther, BioEssays 19, 117-126 (1997).
Klee and Plonsey, Biophys. J. 12 1661-1675 (1972).
Klee and Plonsey, IEEE 23, 347-354 (1976).
Mitchell et al., J. Biomed. Eng. 14, 52-56 (1992).
Plonsey and Barr, IEEE 42 329-336 (1995).
Plonsey and Barr, IEEE 9/10 130-137 (1998.).
Plonsey, Med & Biol. Eng. & Comput. 19 311-315 (1981).
Plonsey, Med. & Biol. Eng. & Comput. 33 337-340 (1995).
Rattay, Neuroscience 89 335-346 (1999).
Reiner et al., “Use of a Membrane Potential—Sensitive Probe to Assess Biological Expression of the Cystic Fibrosis Transmembrane Conductance Regulator” (1995) Human Gene Therapy 6:1275-1283.
Roth, Critical Reviews in Biomed. Eng. 22 263-305 (1994).
Rowell, Biophotonics Int. 12 25-26 (2000).
Schmidt et al., Proc. Natl. Acad. Sci. USA 94 8948-8953 (1997).
Sinha et al., “Simultaneous Optical Recording of Evoked and Spontaneous Transients of Membrane Potential and Intracellular Calium Concentration with High Spatio-Temporal Resolution” (1995) Journal of Neuroscience Methods 60:49-60.
Stone et al., J. Cardiovascular Electrophysiology 10 92-107 (1999).
Svirskis et al., American Phys. Soc. 0022-3077 579-586 (1997).
Tung and Borderies, Biophys. J. 63 371-386 (1992).
Tung et al., Circulation Research 69 722-730 (1991).
Zhou, et al., Circulation Research 83 1003-1014 (1998).
Connolly, P. et al. An Extracellular Microelectrode for Monitoring Electrogenic Cells in Culture. Biosensors and Bioelectronics. 1990. 5:223-234.
Fishler, et al., Mechanisms of Cardiac Cell Excitation with Premature Monophasic and Biphasic Field Stimuli: A Model Study, BIophys J. 70(3):1347-62 Mar. 1996.
Gonzalez, III Jesus E.
Maher Michael P.
Knobbe Martens Olson & Bear LLP
Pak Michael
Vertex Pharmaceuticals (San Diego) LLC
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