Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-31
2009-11-03
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07611850
ABSTRACT:
A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
REFERENCES:
patent: 4072578 (1978-02-01), Cady et al.
patent: 4461304 (1984-07-01), Kuperstein
patent: 4514500 (1985-04-01), Giaever et al.
patent: 4628933 (1986-12-01), Michelson
patent: 4677989 (1987-07-01), Robblee
patent: 4695547 (1987-09-01), Hillard et al.
patent: 4699881 (1987-10-01), Matschke
patent: 4801543 (1989-01-01), Arnold et al.
patent: 4969468 (1990-11-01), Byers et al.
patent: 4970154 (1990-11-01), Chang
patent: 5024223 (1991-06-01), Chow
patent: 5128257 (1992-07-01), Baer
patent: 5178161 (1993-01-01), Kovacs
patent: 5187096 (1993-02-01), Giaever et al.
patent: 5194133 (1993-03-01), Clark et al.
patent: 5405367 (1995-04-01), Schulman et al.
patent: 5422272 (1995-06-01), Papp et al.
patent: 5432086 (1995-07-01), Fränzl et al.
patent: 5439440 (1995-08-01), Hofmann
patent: 5545130 (1996-08-01), Hofmann et al.
patent: 5563067 (1996-10-01), Sugihara et al.
patent: 5571158 (1996-11-01), Bolz et al.
patent: 5643742 (1997-07-01), Malin et al.
patent: 5810725 (1998-09-01), Sugihara et al.
patent: 5855801 (1999-01-01), Lin et al.
patent: 5935155 (1999-08-01), Humayun et al.
patent: 5957958 (1999-09-01), Schulman et al.
patent: 5965452 (1999-10-01), Kovacs
patent: 5972694 (1999-10-01), Mathus
patent: 5981268 (1999-11-01), Kovacs et al.
patent: 6008038 (1999-12-01), Kröger et al.
patent: 6009347 (1999-12-01), Hofmann
patent: 6024702 (2000-02-01), Iversen
patent: 6031711 (2000-02-01), Tennent et al.
patent: 6038478 (2000-03-01), Yuen et al.
patent: 6046002 (2000-04-01), Davis et al.
patent: 6051422 (2000-04-01), Kovacs et al.
patent: 6063260 (2000-05-01), Olesen et al.
patent: 6099960 (2000-08-01), Tennent et al.
patent: 6205016 (2001-03-01), Niu
patent: 6352853 (2002-03-01), King et al.
patent: 6376233 (2002-04-01), Wolf et al.
patent: 6686193 (2004-02-01), Maher et al.
patent: 6969449 (2005-11-01), Maher et al.
patent: 7276206 (2007-10-01), Augustine et al.
patent: 195 29 371 (1997-02-01), None
patent: 0 594 282 (1994-04-01), None
patent: 1 067 378 (2001-01-01), None
patent: 96/41166 (1996-12-01), None
patent: WO97/05922 (1997-02-01), None
patent: WO 98/54294 (1998-12-01), None
patent: WO00/25121 (2000-05-01), None
patent: WO 00/34434 (2000-06-01), None
patent: WO00/68686 (2000-11-01), None
Connolly, P. et al. An extracellular microelectrode for monitoring electrogenic cells in culture. Biosensors and Bioelectronics. 1990. 5:223-234.
U.S. Appl. No. 09/804,457, filed Mar. 12, 2001, Maher et al.
U.S. Appl. No. 09/804,480, filed Mar. 12, 2001, Maher et al.
U.S. Appl. No. 10/620,312, filed Jul. 14, 2003, Maher et al.
U.S. Appl. No. 10/770,861, filed Feb. 2, 2004, Maher et al.
U.S. Appl. No. 10/771,283, filed Feb. 2, 2004, Maher et al.
Arndts, Oral Presentation Abstract, Second International Cell Analysis Products Users Meeting in Hilton Head Island, South Carolina, USA (Jun. 3-5, 1998).
Barr and Plonsey, Biophys. J. 61, 1164-1175 (1992).
Barr and Plonsey, IEEE 42, 1185-11911 (1995).
Brust-Mascher, I et al., “Calcium Waves Induced by Large Voltage Pulses in Fish Keratocytes”, Biophysical Journal, (1998) 75(4): 1669-1678.
Cartee and Plonsey, IEEE 39, 76-85 (1992).
Cartee and Plonsey, Med & Biol. Eng. & Comp. 30 389-398 (1992).
Denyer, J et al., “HTS Approaches to Voltage-Gated Ion Channel Drug Discovery Today”, (1998) 3(7): 323-332.
Eppich et al., Nature Biotech. 18, 882-887 (2000).
Giuliano, K.A., et al., “Fluorescent-protein biosensors: new tools for drug discovery”, Trends in Biotechnology, vol. 16, No. 3, pp. 135-140, (Mar. 1998).
González, J.E., et al., “Voltage sensing by fluorescence resonance energy transfer in single cells”, Biophysical Journal, vol. 69, No. 4, pp. 1272-1280, (Oct. 1995).
González, J.E., et al., “Cell-based assays and instrumentation for screening ion-channel targets”, Drug Discover Today, vol. 4, No. 9, pp. 431-439, (Sep. 1999).
Greenberg, et al. IEEE 46, 505-514 (1999).
Gross, et al. Biophys. J. 50, 339-348 (1986).
Jacobs et al., “Control of Action Potential-Induced Ca2=Signaling in the Soma of Hippocampal Neurons by Ca2+Release from Intracellular Stores”, (1997) Journal of Neuroscience 17(11):4129-4135.
Jentsch and Günther, BioEssays 19, 117-126 (1997).
Klee and Plonsey, Biophys. J. 12 1661-1675 (1972).
Klee and Plonsey, IEEE 23, 347-354 (1976).
Mitchell et al., J. Biomed. Eng. 14, 52-56 (1992).
Plonsey and Barr, IEEE 42 329-336 (1995).
Plonsey and Barr, IEEE 9/10 130-137 (1998.).
Plonsey, Med & Biol. Eng. & Comput. 19 311-315 (1981).
Plonsey, Med. & Biol. Eng. & Comput. 33 337-340 (1995).
Rattay, Neuroscience 89 335-346 (1999).
Reiner et al., “Use of a Membrane Potential—Sensitive Probe to Assess Biological Expression of the Cystic Fibrosis Transmembrane Conductance Regulator” (1995) Human Gene Therapy 6:1275-1283.
Roth, Critical Reviews in Biomed. Eng. 22 263-305 (1994).
Rowell, Biophotonics Int. 12 25-26 (2000).
Schmidt et al., Proc. Natl. Acad. Sci. USA 94 8948-8953 (1997).
Sinha et al., “Simultaneous Optical Recording of Evoked and Spontaneous Transients of Membrane Potential and Intracellular Calium Concentration with High Spatio-Temporal Resolution” (1995) Journal of Neuroscience Methods 60:49-60.
Stone et al., J. Cardiovascular Electrophysiology 10 92-107 (1999).
Svirskis et al., American Phys. Soc. 0022-3077 579-586 (1997).
Tung and Borderies, Biophys. J. 63 371-386 (1992).
Tung et al., Circulation Research 69 722-730 (1991).
Zhou, et al., Circulation Research 83 1003-1014 (1998).
Fishler, et al., Mechanisms of Cardiac Cell Excitation with Premature Monophasic and Biphasic Field Stimuli: A Model Study, Blophys J. 70(3):1347-62 Mar. 1996.
Gonzalez, III Jesus E.
Maher Michael P.
Knobbe Martens Olson & Bear LLP
Pak Michael
Vertex Pharmaceuticals (San Diego) LLC
LandOfFree
Ion channel assay methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ion channel assay methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ion channel assay methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4125256