Ion binding compounds, radionuclide complexes, methods of making

Details Ion binding compounds, radionuclide complexes, methods of making Ion binding compounds, radionuclide complexes, methods of making

1998-11-10

2000-06-13

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 11, 534 15, 534 13, 423 9, C07F 502

Patent

active

060751304

ABSTRACT:
The invention pertains to compounds for binding lanthanide ions and actinide ions. The invention further pertains to compounds for binding radionuclides, and to methods of making radionuclide complexes. Also, the invention pertains to methods of extracting radionuclides. Additionally, the invention pertains to methods of delivering radionuclides to target locations. In one aspect, the invention includes a compound comprising: a) a calix[n]arene group, wherein n is an integer greater than 3, the calix[n]arene group comprising an upper rim and a lower rim; b) at least one ionizable group attached to the lower rim; and c) an ion selected from the group consisting of lanthanide and actinide elements bound to the ionizable group. In another aspect, the invention includes a method of extracting a radionuclide, comprising: a) providing a sample comprising a radionuclide; b) providing a calix[n]arene compound in contact with the sample, wherein n is an integer greater than 3; and c) extracting radionuclide from the sample into the calix[n]arene compound. In yet another aspect, the invention includes a method of delivering a radionuclide to a target location, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising at least one ionizable group; b) providing a radionuclide bound to the calix[n]arene compound; and c) providing an antibody attached to the calix[n]arene compound, the antibody being specific for a material found at the target location.

REFERENCES:
patent: 5205946 (1993-04-01), Cook et al.
patent: 5210216 (1993-05-01), Harris et al.
patent: 5453220 (1995-09-01), Swager et al.
patent: 5607591 (1997-03-01), Dozol et al.
patent: 5622687 (1997-04-01), Krishnan et al.
patent: 5866087 (1999-02-01), Dozol et al.
Johann et al, J. Chem. Soc. Perkin Trans, 2, No. 6, pp. 1183-1192, "Solvent vs. Counterion acceleration of enantioseletive carbo and hetero Dielc--Act Alder reactions", 1997.
Sabbatini et al, Inurganico Chimica Acta, 25-2, pp. 19-24, "Luminescence of Eu 3t and Tb3t complexes of a new macrobicycle ligands derived from p-tert-butyl calix [4]avene", 1996.
Sabbatani et al, J. Chem. Soc. Chem. Commun. pp. 878-879, Encapsulation of Lanthanide Ions in Calixarene Receptors. A Strongly Luminescent terbium 3t complex, 1990.
Chang et al, J. Chem. Soc. Perkin Transl, pp. 211-214, "New Metal Cation--Selective Ionophores Derived from Calixarenes. Their Synthesis and Ion-Binding Properties", 1986.
Dozol et al, Value Adding Solvent Extraction, [Pap. ISec '96], vol. 2, pp. 1333-1338, "Extraction and Transport of Radioactive Cations through S. C.M.S with functionalized Calixarenes", 1996.
Seangproserakij, J. Org. Chem, 1994, 59, pp. 1741-1744, "Schoff Base p-tert-butylcalix[4]arenes. Synthesis and Metal Ion Complexation", 1994.
Hampton et al, Inorganic Chem, 36, pp. 2956-2959, "Selective Binding of Trivalent Metals by Hexahomotrioxacalix[3]arene Macromolecules: Determination of Metal binding Constants and metal Transport Studies", 1997.
Harrowfield et al, J. Chem. Soc. Dalton Trans, pp. 976-985, "Actinide complexes of the calixarenes. Part I--Synthesis and crystal structures of bis(homo-oxa)-p-tert-betycalix[4]arene and it uranyl ion complex", 1991.

Affiliated with

Also associated with

Rating

Ion binding compounds, radionuclide complexes, methods of making does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ion binding compounds, radionuclide complexes, methods of making, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ion binding compounds, radionuclide complexes, methods of making will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2069631