Iodothyronine polymers

Details Iodothyronine polymers Iodothyronine polymers

1997-08-25

1999-06-08

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530326, 530327, 530328, 530329, 530330, A61K 3816

Patent

active

059105690

ABSTRACT:
Iodothyronine polymers having a plurality of recurring units of formula I ##STR1## in which A is iodo and B, C and D are independently H or iodo are described. Polymers in which A and C are iodo and B and D are independently H or iodo and in which substantially all of the recurring units are L-stereoisomers, have utility in treating thyroid hormone deficiencies.

REFERENCES:
patent: 4552864 (1985-11-01), Antoni
Rawitch, Biochem. Biophys. Res. Commun. 118, 423, 1984.
Marriq, Biochem. Biophys. Res. Commun 112, 206, 1983.
Orten, Human Biochemistry, 9.sup.th Ed., pp. 401-405, 1975.
Pawelczak, Pept. Proc. Eur. Pept. Symp. 16.sup.th, 264, 1981.

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