Iodothyronine immunoassays employing HMS as TBP blocking agent

Details Iodothyronine immunoassays employing HMS as TBP blocking agent Iodothyronine immunoassays employing HMS as TBP blocking agent

1983-07-05

1986-11-11

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435810, 436500, 436545, 436804, 436808, G01N 3353, G01N 33534, G01N 33535

Patent

active

046222936

ABSTRACT:
An improved immunoassay method, reagent means, test kit, and test device for determining an iodothyronine, e.g., thyroxine (T-4), in a biological fluid, usually serum or plasma, wherein 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (HMS), or a salt thereof, is employed as a blocking agent for the binding of iodothyronines to thyroxine binding protein (TBP). The present invention is particularly advantageous as applied to homogeneous competitive binding iodothyronine immunoassays employing labels which are participants in enzyme-catalyzed reactions. Such labels include enzyme substrates, coenzymes, enzyme inhibitors, enzyme prosthetic groups, and enzymes.

REFERENCES:
patent: 4468469 (1984-08-01), Atkinson

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