Iodophor-containing suppository

Details Iodophor-containing suppository Iodophor-containing suppository

1986-07-30

1988-07-05

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Lymphokine

424150, 424433, 514966, 514967, A61K 3179, A61K 3318

Patent

active

047553782

ABSTRACT:
Iodophor-containing suppositories are provided with improved rate of iodine release from the suppository. The suppository composition comprises an iodophor, a water soluble suppository base, at least one water soluble sugar having a molecular weight of between about 90 and 550, and water in an amount of at least about 30% by weight. The molecular weight of the sugar is preferably between about 150 and 370. The preferred iodophors are providone iodine and polydextrose iodine. The preferred suppository bases are gelling polysaccharides and the preferred sugars are monosaccharides, disaccharides and sugar alcohols. The rate of iodine release is improved because of the high concentration of water together with the presence of the low molecular weight sugar.

REFERENCES:
patent: 2975099 (1961-03-01), Goyan et al.
patent: 3234091 (1966-02-01), Lang et al.
patent: 4576818 (1986-03-01), Shetty

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