Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1993-05-11
1995-01-10
Mars, Howard T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, C07C40100
Patent
active
053807200
ABSTRACT:
Biologically active 1.alpha.-hydroxy-22-iodinated vitamin D.sub.3 compounds and a process for the preparation of 1.alpha.-hydroxy-22-iodinated vitamin D.sub.3 compounds are disclosed. The 22-iodo-vitamin D.sub.3 compounds show relatively high binding affinity for the vitamin D receptor demonstrating their potential for high in vivo biological activity. Further, these compounds induce relatively high differentiation of malignant cells. Also, these 22-iodo compounds show high in vivo calcium transport activity with little or no bone calcium mobilization activity. These compounds thus show promise in the treatment of osteoporosis.
REFERENCES:
patent: 5061699 (1991-10-01), DeLuca et al.
patent: 5182393 (1993-01-01), Yiannikouros et al.
DeLuca Hector F.
Sicinski Rafal R.
Kestler Kimberly J.
Mars Howard T.
Wisconsin Alumni Research Foundation
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