Organic compounds -- part of the class 532-570 series – Organic compounds – 9,10-seco-cyclopentanohydrophenanthrene ring system or...
Patent
1993-05-11
1994-12-06
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
9,10-seco-cyclopentanohydrophenanthrene ring system or...
C07C40100
Patent
active
053712498
ABSTRACT:
Biologically active 1.alpha.-hydroxy-22-iodinated vitamin D.sub.3 compounds and a process for the preparation of 1.alpha.-hydroxy-22-iodinated vitamin D.sub.3 compounds are disclosed. The 22-iodovitamin D.sub.3 compounds show relatively high binding affinity for the vitamin D receptor demonstrating their potential for high in vivo biological activity. Further, these compounds induce relatively high differentiation of malignant cells. Also, these 22-iodo compounds show high in vivo calcium transport activity with little or no bone calcium mobilization activity. These compounds thus show promise in the treatment of osteoporosis.
DeLuca Hector F.
Sicinski Rafal R.
Kestler Kimberly J.
Reamer James H.
Wisconsin Alumni Research Foundation
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