Iodine derivatives of tetrabenazine

Details Iodine derivatives of tetrabenazine Iodine derivatives of tetrabenazine

1992-02-28

1994-01-11

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D45506

Patent

active

052783081

ABSTRACT:
Compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are independently selected from the group consisting of H, OH, OCH.sub.3, and Halogen or R.sub.1 and R.sub.2 can be taken together to form --O--CH.sub.2 --O--;

REFERENCES:
patent: 3053845 (1962-09-01), Tretter
patent: 3314966 (1967-04-01), Brossi et al.
patent: 3393198 (1968-07-01), Unger et al.
Brossi, et al., "16. Syntheseversuche in der Emetin Reihe 1. Mitteilung 2-Oxo-hydrobenzo[a]chinolizine.sup.1).sup.2)" Helv. Chim. Acta. 41: 119-139, 1958.
Clarke, et al., "A Series of Hexahydro [1,4]oxazino[3,4-a]isoquinolines as Potential Neuroleptics." J. Med. Chem. 21: 785-791 (1978).
Cooper, et al., Biochemical Basis of Neurochemistry, 5th ed., Oxford University Press, New York: 290 (1986).
Darchen, et al., "Quantitative Autoradiography of the Rat Brain Vesicular Monamine Transporter Using the Binding of [.sup.3 H]Dihydrotetrabenazine and 7-Amino-8-[.sup.125 I]Iodoketanserin." Neurosci 33: 341-349 (1989).
Fahrenholtz, et al., "Octahydrophenanthrene Analogs of Tetrabenazine" J. Med. Chem. 9: 304-310 (1967).
Harnden, et al., "2-Thio-1,3,4,6,7,11b-hexahydro-9, 10-dimethoxy-2H-benzo[a]quinolizines." J. Med. Chem. 10: 1183-1184 (1967).
Henry, et al., "Radioligands of the Vesicular Monoamine Transporter and Their Use as Markers of Monoamine Storage Vesicles (Commentary)" Biochem Pharmacol 38: 2395-2404 (1989).
Kaiser, et al., "Antipsychotic Agents", Burger's Medicinal Chemistry 4th Ed., ed. by Wolf M. E., Wiley Interscience, N.Y.: 859-964 (1981).
Lednicer, et al., The Organic Chemistry of Drug Synthesis Wiley-Interscience, Inc., N.Y.: 349-361 (1977).
Masuo, et al., "[.sup.3 H]Dihydrotetrabenazine, a new marker for the visualization of dopaminergic denervation in the rate striatum." Neurosci Lett 114: 45-50 (1990).
Meshgin-Azarian, et al., "Distribtution of [.sup.3 H]Dihydrotetrabenazine Binding in Bovine Striagal Subsynaptic Fracations: Enrichment of Higher Affinity Binding in a Synaptic Vesicle Fraction." J. Neurochem. 50: 824-830 (1988).
Near, J. A., "[.sup.3 H]Dihydrotetrabenazine Binding to Bovine Striatal Synaptic Vesicles" Mol Pharmacol. 30: 252-257 (1986).
Pletscher, et al., "Benzoquinolizine Derivatives: A New Class of Monoamine Decreasing Drugs with Psychotropic Action." Rev. Neurobiol. 4: 275-306 (1962).
Saner, et al., "A Benzo[a]Quinolizine Derivative with A Neuroleptic-Like Action on Cerebral Monoamine Turnover" J. Pharmacol. Exp. Ther. 203: 556-563 (1977).
Scherman et al., "[.sup.3 H]Dihydrotetrabenazine, a New In Vitro Monoaminergic Probe for Human Brain." J. Neurochem. 50: 1131-1136 (1988).
Scherman, et al., "Hydrophobicity of the Tetrabenzine-Binding Site of the Chromaffin Granule Monoamine Transporter". Mol. Pharmacol 33: 72-77 (1988).
Suchi, et al., "Covalent Modification of the Amine Transporter with N,N.sup.1 -Dicyclohexylcarbodiimide." Biochem 30: 6490-6494 (1991).
Darchen, et al., "Ketanserin Binds to the Monoamine Transporter of Chromaffin Granules and of Synaptic Vesicles", Molecular Pharmacology 33: 672-677 (1988).
Scherman, Daniel, "Dihydrotetrabenazine Binding and Monoamine Uptake in Mouse Brain Regions", Journal of Neurochemistry, vol. 47, No. 2: 331-339 (1986).

Affiliated with

Also associated with

Rating

Iodine derivatives of tetrabenazine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Iodine derivatives of tetrabenazine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Iodine derivatives of tetrabenazine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1632611