Iodinated neuroprobe for mapping monoamine reuptake sites

Details Iodinated neuroprobe for mapping monoamine reuptake sites Iodinated neuroprobe for mapping monoamine reuptake sites

1994-01-24

1995-08-08

Geist, Gary

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

514304, A61K 5100

Patent

active

054396662

ABSTRACT:
An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R=a C.sub.n H.sub.2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including .sup.n F where n=18 or 19, or a .sup.m C.sub.n H.sub.2n+1 group where n=1-6 and where m=11 or 14 for at least one .sup.m C;

REFERENCES:
patent: 3813404 (1974-05-01), Clarke et al.
patent: 4942231 (1990-07-01), Mertens
patent: 5098996 (1992-03-01), Jacobson et al.
patent: 5104638 (1992-04-01), Nosco
patent: 5128118 (1992-07-01), Carroll et al.
patent: 5186921 (1993-02-01), Kung et al.
patent: 5200169 (1993-04-01), Wilbur et al.
R. Dagani, "Cocaine analog for Parkinsonism Studies", C&EN 25-26, Oct. 1991.
"Membrane Receptors", Poster 342, The FASEB Journal 4:A325, Feb. 26, 1990.
Boja et al., "[.sup.125 l]RTI-55: A Potent Ligand for Dopamine Tarnsporters", Europ. J. of Pharm. 194:133-134, 1991.
Milius et al., "Synthesis and Receptor Binding of N-Substituted Tropane Derivatives. High-Affinity Ligands for the Cocaine Receptor", J. of Med. Chem. 34:No 5, 1991.
Clarke et al., "Compounds Affecting the Central Nervous System . . . ", J. of Med. Chem. 16:1260-1267, 1973.
Seitz et al., "Tritiodestannylation. Synthesis of a Specifically Labelled . . . ", Synthetic Communications 11:281-286, 1981.
"Abstracts of Panels and Posters", American College of Neuropsychopharmacology, 29th Annual Meeting, 1990.
Madras et al., "Cocaine Receptors Labeled by . . . ", Mol. Pharm. 36:518-524, 1989.
Boja et al., "New, Potent Cocaine Analogs: Ligand Binding and . . . ", Europ. J. of Pharm. 184:329-332, 1990.
Innis et al., "Single Photon Emission Computed Tomography Imaging . . . ", Europ. J. of Pharm. 200:369-370, 1991.
Neumeyer et al., "[.sup.125 l]-2.beta.-Carbomethoxy-3.beta.-(4-iodophenyl)tropane: . . . ", J. Med. Chem. 34:3144-3146, 1991.

Affiliated with

Also associated with

Rating

Iodinated neuroprobe for mapping monoamine reuptake sites does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Iodinated neuroprobe for mapping monoamine reuptake sites, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Iodinated neuroprobe for mapping monoamine reuptake sites will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-969611