Iodinated neuroprobe for mapping monoamine reuptake sites

Details Iodinated neuroprobe for mapping monoamine reuptake sites Iodinated neuroprobe for mapping monoamine reuptake sites

1995-06-06

1997-12-16

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 181, 514304, 546124, A61K 5104, A01N 4342, C07D45102

Patent

active

056981791

ABSTRACT:
An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein: R=aryl, substituted aryl, heterocyclic, CO(CH.sub.2).sub.n Y, (CH.sub.2).sub.n CHF.sub.2, and (CF.sub.2).sub.n Y, wherein:

REFERENCES:
patent: 3813404 (1974-05-01), Clarke et al.
patent: 4794178 (1988-12-01), Coenen et al.
patent: 4942231 (1990-07-01), Mertens
patent: 5098996 (1992-03-01), Jacobson et al.
patent: 5104638 (1992-04-01), Nosco
patent: 5128118 (1992-07-01), Carroll et al.
patent: 5186921 (1993-02-01), Kung et al.
patent: 5200169 (1993-04-01), Wilbur et al.
patent: 5369113 (1994-11-01), Moldt et al.
"Abstracts of Panels and Posters", American College of Neuropsychopharmacology, 29th Annual Meeting, 1990.
Boja et al., "New, Potent Cocaine Analogs: Ligand Binding and . . . ", Europ. J. of Pharm. 184:329-332, 1990. Transporters", Europ. J. of Pharm. 194: 133-134, 1991.
Clarke et al., "Compounds Affecting the Central Nervous System . . . ", J. of Med. Chem. 16:1260-1267, 1973.
Dagani, R., "Cocaine analog for Parkinsonism Studies", C&EN 25-26, Oct. 1991.
Madras et al., "Cocaine Receptors Labeled by . . . ", Mol. Pharm. 36:518-524, 1989.
"Membrane Receptors", Poster 342, The FASEB Journal 4:A325, Feb. 26, 1990.
Milius et al., "Synthesis and Receptor Binding of N-Substituted Tropane Derivatives. High-Affinity Ligands for the Cocaine Receptor", J. of Med. Chem. 34:No. 5, 1991.
Seitz et al., "Tritiodestannylation. Synthesis of a Specifically Labelled . . . ", Synthetic Communications 11:281-286, 1981.

Affiliated with

Also associated with

Rating

Iodinated neuroprobe for mapping monoamine reuptake sites does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Iodinated neuroprobe for mapping monoamine reuptake sites, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Iodinated neuroprobe for mapping monoamine reuptake sites will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-202834