Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-09-30
1995-05-16
Ramsuer, Robert W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549229, 549448, 549479, 546302, 558270, 558275, 558276, C07C 6978, C07D31734, C07D33332
Patent
active
054162238
ABSTRACT:
Water insoluble iodinated esters of formula (I), in which R.sup.1 is a substituted or unsubstituted C.sub.1-20 aliphatic, C.sub.7-20 araliphatic or C.sub.6-20 aryl group or a C.sub.1-20 heterocyclic group having one or more hereto atoms selected from O, S and N; R.sup.2 is hydrogen or a substituted or unsubstituted C.sub.1-6 aliphatic, C.sub.6-10 aryl or C.sub.7-20 araliphatic group; and R.sup.3 is a group as defined above for R.sup.1, which may be the same as or different from R.sup.1, or R.sup.2 and R.sup.3 together represent a substituted or unsubstituted C.sub.1-4 alkylene group, the molecule containing at least one iodine atom and being metabolisable to products which are soluble in body fluids and are physiologically acceptable. The esters are useful in X-ray and ultrasound imaging, especially liver and spleen imaging.
REFERENCES:
patent: 3795698 (1974-03-01), Soulal et al.
patent: 4018783 (1977-04-01), Soulal et al.
patent: 4440692 (1984-04-01), Kalbacher et al.
Chemical Abstracts Registry Handbook (1965-1971) registry Nos. 12700-00-0 through 17799-99-4, p. 5556R.
Wiegert, Chemical Abstracts, vol. 84 (1976) No. 84: 89851h.
Tilly, Chemical Abstracts, vol. 84 (1976) No. 184,889k.
Klaveness Jo
Strande Per
Nycomed Imaging AS
Ramsuer Robert W.
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