Iodinated borane cage molecules as X-ray contrast media

Details Iodinated borane cage molecules as X-ray contrast media Iodinated borane cage molecules as X-ray contrast media

1993-08-16

1996-02-06

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 187, 424 94, 424 943, 423276, 423284, 423286, 423287, 423292, C07H 2300, C07H 506, A61K 4904

Patent

active

054896738

ABSTRACT:
Highly iodinated borane and carborane cage molecules, having from 60% to 90% w/w iodine, are disclosed as new and useful X-ray contrast media when combined with a pharmaceutically acceptable carrier. The inclusion of appropriate functional group substituents, such as hydrophilic moieties, increases solubility and lowers toxicity.

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Soloway et al., "Investigation of the Use of N.sub.A2 B.sub.12 I.sub.12 as an Intravascular Contrast Media", Angiology, vol. 15, No. 6, pp. 273-275, (Jun., 1964).

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