Iodinated borane cage molecules as X-ray contrast media

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 943, 424 944, A61K 3318

Patent

active

056793227

ABSTRACT:
Highly iodinated borane and carborane cage molecules, having from 60% to 90% w/w iodine, are disclosed as new and useful X-ray contrast media when combined with a pharmaceutically acceptable carrier. The inclusion of appropriate functional group substituents, such as hydrophilic moieties, increases solubility and lowers toxicity.

REFERENCES:
patent: 5256394 (1993-10-01), Spielvogel et al.
patent: 5272250 (1993-12-01), Spielvogel et al.
patent: 5280119 (1994-01-01), Spielvogel et al.
patent: 5286853 (1994-02-01), Spielvogel et al.
patent: 5455022 (1995-10-01), Miura et al.
patent: 5489673 (1996-02-01), Wilbur
patent: 5545397 (1996-08-01), Spielvogel et al.
Jakinek et al., Collection of Czechoslovak Chemical Communications, vol. 51, pp. 819-829, 1986.
Sieckhaus et al., Inorganic Chemistry, vol. 8, pp. 2452-2457, 1969.
Jelinek et al., Polyhedron, vol. 6, pp. 1981-1986, 1987.
Zakharkin et al., Journal of Organometallic Chemistry, vol. 267, pp. 81-91, 1984.
Plesek et al., Polyhedron, vol. 3, pp. 1351-1355, 1984.
Zakharkin et al., Journal of Organometallic Chemistry, vol. 226, pp. 217-222, 1982.
Knoth et al., Inorganic Chemistry, vol. 10, pp. 598-605, 1971.
Knoth et al., Inorganic Chemistry, vol. 3, pp. 159-167, 1964.
Soloway et al., "Investigation of the Use of Na.sub.2 B.sub.12 I.sub.12 as an Intravascular Contrast Media," Angiology, vol. 15, No. 6, pp. 273-175, Jun. 1964.
Stibr, Chemical Reviews, vol. 92, No. 2, pp. 225-250, Apr. 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Iodinated borane cage molecules as X-ray contrast media does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Iodinated borane cage molecules as X-ray contrast media, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Iodinated borane cage molecules as X-ray contrast media will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1004475

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.