Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Patent
1994-03-10
1996-01-30
Dees, Jose G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
560103, 560106, 560111, 560 47, 424 94, 424 944, C07C22956, A61K 4904
Patent
active
054881331
ABSTRACT:
Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20;
R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, acetamidoaryl, --COO-alkyl, --COO-aryl, --COO-aralkyl, --CO-alkyl, --CO-aryl, --CO-heterocyclyl, cyano or heterocyclyl;
R.sup.5 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, heterocyclyl, or a Z-CO.sub.2 -CR.sup.1 R.sup.2 (CR.sup.3 R.sup.4).sub.n group, wherein Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are as defined above, m is an integer from 0 to 10, p is an integer from 0 to 10, and m+p.gtoreq.1 are useful as contrast agents in x-ray imaging compositions and methods.
REFERENCES:
patent: 3097228 (1963-07-01), Larsen
patent: 3144479 (1964-08-01), Obendorf
patent: 4567034 (1986-01-01), Charles et al.
patent: 4607123 (1986-08-01), Schuster et al.
patent: 5260478 (1993-11-01), Bacon et al.
patent: 5346688 (1994-09-01), Bacon et al.
patent: 5360604 (1994-11-01), Ruddy et al.
patent: 5368837 (1994-11-01), Baker et al.
patent: 5384107 (1995-01-01), Singh et al.
CA 116:255269 (1992).
CA 82:138711 (1974).
CA 71:50424 (1969).
Bacon Edward R.
Robinson Shaughnessy
Singh Baldev
Dees Jos,e G.
Eastman Kodak Company
Frazier Barbara S.
Rosenstein Arthur H.
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