Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1994-08-03
1995-01-24
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
560 47, 560 45, 560 37, A61K 4904
Patent
active
053841077
ABSTRACT:
Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 6;
R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;
R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino;
Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; and
R.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods.
REFERENCES:
patent: 3772376 (1973-11-01), Ekstrand et al.
J. Med. Chem. 20(8), 1086-90 Brain et al., 1977.
Chemical Abstracts 76:24919 b; 1971 Search Report of Structures in 76: 24919b.
Bacon Edward R.
Illig Carl R.
Singh Baldev
Barts Samuel
Davis William J.
Dees Jos,e G.
Sterling Winthrop Inc.
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