Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Reexamination Certificate
2006-10-10
2009-06-30
Bertoglio, Valarie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
C800S009000, C800S012000, C800S013000
Reexamination Certificate
active
07554003
ABSTRACT:
The present invention claims an invertebrate animal that has been modified to express a set of genes, the set comprising the gene coding for a modified version of the gamma subunit of AMP-activated protein kinase (AMPKg). According to the invention, the animal displays an identifiable phenotype related to lipid metabolism and neurodegeneration. This animal provides a model of neurodegenerative diseases, particularly Alzheimer's disease, and may be useful for screening and testing modulating agents, substances and therapeutic compounds for neurodegenerative disorders.
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patent: WO 02/057455 (2002-07-01), None
patent: WO 03/028446 (2003-04-01), None
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Kretschmar Doris
Tschaepe Jakob-Andreas
Bertoglio Valarie
Evotec Neurosciences GmbH
Jacobson & Holman PLLC
Montanari David
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