Invasive microorganisms

Details Invasive microorganisms Invasive microorganisms

1994-03-21

1997-09-02

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

4352528, 4352523, 4242351, 4242581, A61K 39112, A61K 39116, C12N 120, C12N 121

Patent

active

056629087

ABSTRACT:
Novel methods and microorganisms are provided, where novel genetic mammalian cell invasive capability is imparted to a microorganism by the introduction of an exogenous ail or hil gene. The resulting organisms are then capable of binding to mammalian cells and are transferred to the cytoplasm. Other novel genetic capabilities may be imparted to the unicellular microorganism, which may serve as a vaccine for one or more pathogens or may introduce genetic capabilities or foreign molecules into a mammalian host cell. The sequences may be used for an in vitro screen for pathogenicity. Mutant microorganisms having an attenuated invasive phenotype are also disclosed wherein one or more invasive genes have been modified.

REFERENCES:
Wilson, D.R. et al. 1990 Res. Microbiol. vol. 141 pp. 827-830.
Galan, J.E. et al. 1989 Proc. Natl. Acad. Sci. USA vol. 86 pp. 6383-6387.
Miller, I. et al. 1989, Infect. Immun. vol. 57, pp. 2758-2763.
Elsinghorst, E.A. 1989, Proc. Natl. Acad. Sci. USA vol. 86 pp. 5173-5177.
Hormache, C. 1991, J. Immunol. Meth. vol. 142 pp. 113-120.
Galan, J.E. et al. 1991, Infect. Immun. vol. 59, pp. 2901-2908.

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