Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Patent
1998-08-10
2000-05-09
Dvorak, Linda C. M.
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
600322, 356 39, A61B 500
Patent
active
060615818
ABSTRACT:
Methods for determining invasively and in vivo pH in a human. The invasive method includes the steps of: generating light at three or more different wavelengths in the range of 1000 nm to 2500 nm; irradiating blood; measuring the intensities of the wavelengths emerging from the blood to obtain a set of at least three spectral intensities v. wavelengths; and determining the unknown values of pH. The determination of pH is made by using measured intensities at wavelengths that exhibit change in absorbance due to histidine titration. Histidine absorbance changes are due to titration by hydrogen ions. The determination of the unknown pH values is performed by at least one multivariate algorithm using two or more variables and at least one calibration model. The determined pH values are within the physiological ranges observed in blood containing tissue.
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patent: 5103829 (1992-04-01), Suzuki et al.
patent: 5792050 (1998-08-01), Alam et al.
Alam Mary K.
Robinson Mark R.
Dvorak Linda C. M.
Morgan DeWitt M.
Yarnell Bryan K.
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