Invasion assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Details

C435S091200, C536S023100, C536S024300

Reexamination Certificate

active

06964848

ABSTRACT:
The invention relates to improved methods of detecting and characterizing polynucleotide sequences and variations in polynucleotide sequences. The invention further relates to a device that can be used to detect and characterize polynucleotide sequences and variations in polynucleotide sequences.

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Ryan et al., “Genotyping of Factor V Leiden in clinical samples using the Invader (TM)-Fret microtiter plate assay”, American Journal of Pathology 153(5): 1649 (1998).
Fasman, 1989,Practical Handbook of Biochemistry and Molecular Biology, UV Spectral Characteristics and Acidic Dissociation Constants of 280 Alkyl Bases, Nucleosides, and Nucleotides, pp. 385-394, CRC Press, Boca Raton, FL.
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Ryan, D. et al.,Molecular Diag., Non-PCR-Dependent Detection of the Factor V Leiden Mutation From Genomic DNA Using a Homogeneous Invader Microtiter Plate Assay, 4(2):135-144 (1999).
Siegel, S.,Nonparametric Statistics, McGraw-Hill, New York, p. 52, 1956.

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