Inulin compositions in gamma polymorphic form

Details Inulin compositions in gamma polymorphic form Inulin compositions in gamma polymorphic form

1990-03-30

1991-09-24

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514885, 424 92, 424 93, 536 41, 536 11, 536123, 536127, A61K 31715, A61K 3902, A01N 6500, C08B 3718

Patent

active

050514083

ABSTRACT:
A process for preparing gamma inulin comprising the steps of (a) recrystallizing crude inulin from water at a temperature below 37.degree. C. to obtain a suspension, (b) heating the suspension at a temperature of from about 25.degree. to 45.degree. C. for about 1-3 days, (c) further heating the suspension at a temperature of about 40.degree. to 55.degree. C. for about 0.5 to 1.5 hours, and (d) isolating insoluble gamma inulin from the suspension. A composition comprising particles of inulin or an inulin derivative in the gamma polymorphic form is characterized in that the particles have a low rate of solution in aqueous media above 30.degree. C., particularly above 37.degree. C. The composition is effective as the active component of an immunotherapeutic preparation for activation of the alternative pathway of complement, or for antitumor treatment.

REFERENCES:
Phelps; Biochem. J. 95:41-47 (1965).
Sommerman et al.; Biochem. Biophys. Res. Commun. 122(1):319-324 (1984).
Cooper et al.; Molecular Immunology 23(8):895-901 (1986).
Cooper et al.; Molecular Immunology 23(8):903-908 (1986).
Cooper et al.; Int. J. Cancer 33:683-687 (1984).
Cooper; Advances in Immunity and Cancer Therapy vol. 1 Ed. Ray; pp. 125-166 Chap. 4 (Sep. 1985).

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