Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2004-07-14
2008-10-28
Strzelecka, Teresa E (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07442782
ABSTRACT:
The present invention provides methods for identifying individuals not at risk for developing myotonic dystrophy type 2 (DM2), and individuals that have or at risk for developing DM2. The present invention also provides isolated polynucleotides that include a repeat tract within intron 1 of the zinc finger protein 9.
REFERENCES:
patent: 6812339 (2004-11-01), Venter et al.
patent: 2003/0108887 (2003-06-01), Ranum et al.
patent: 01/72799 (2001-10-01), None
Buck et al., Biotechniques, vol. 27, No. 3, pp. 528-536, 1999).
Sequence Information Contained in Celera Accession No. 2HTBKUAD8C, “Conting Overlapping ZNF”, pp. 1-310.
Alwazzan et al., “Myotonic Dystrophy is associated with a reduced level of RNA from the DMWD allele adjacent to the expanded repeat,”Hum. Mol. Genet., 1999; 8(8):1491-7.
Aminoff et al., “Automotive function in myotonic dystrophy,”Archives of Neurology, Jan. 1985;42(1):16.
Andrews et al., “The glycoprotein Ib-IX-V complex in platelet adhesion and signaling,”Thromb Haemost, 1999; 82(2):357-64.
Armas et al., “Primary structure and developmental expression of Bufoarenarum cellular nucleic acid-binding protein: changes in subcellular localization during early embryogenesis,”Dev. Growth Differ., Feb. 2001; 43(1):13-23.
Boucher et al., “A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat,”Hum. Mol. Genet., 1995; 4(10):1919-25.
Brook et al., “Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member,”Cell, Feb. 21, 1992; 68(4):799-808.
Buxton et al., “Detection of an unstable fragment of DNA specific to individuals with myotonic dystrophy,”Nature, Feb. 6, 1992; 335(6360):547-8.
Davis et al., “Expansion of a CUG trinucleotide repeat in the 3′ untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts,”Proc. Natl. Acad. Sci. USA, Jul. 8, 1997; 94(14):7388-93.
Day et al., “Clinical and genetic characteristics of a five-generation family with a novel form of myotonic dystrophy (DM2),”Neuromuscul. Disord, 1999; 9(1):19-27.
Flink et al., “Organization of the gene encoding cellular nucleic acid-binding protein,”Gene, 1995; 163(2):279-82.
Fu et al., “An unstable triplet repeat in a gene related to myotonic muscular dystrophy,”Science, Mar. 6, 1992; 255(5049):1256-58.
Fu et al., “Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy,”Science, Apr. 9, 1993; 260(5105):235-8.
Groenen et al., “Expanding complexity in myotonic dystrophy,”Bioessays, Nov. 1998; 20(11):901-12.
Harley et al., “Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy,”Nature, Feb. 6, 1992; 335(6360):545-6.
Harper, “Myotonic Dystrophy,” Second Edition, W.B. Sanders, London 1989. Title Page and Table of Contents.
Helderman-van den Enden, “Monozygotic twin brothers with the fragile X syndrome: different CGG repeats and different mental capacities,”J. Med. Genet., 1999; 36(3):253-7.
Kawaguchi et al., “CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1,”Nat. Genet., 1994; 8(3):221-8.
Khajavi et al., “Mitotic drive' of expanded CTG repeats in myotonic dystrophy type 1 (DM1),”Hum. Mol. Genet., 2001; 10(8):855-63.
Klesert et al., “Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP,”Nat. Genet., Aug. 1997; 16(4):402-6.
Klesert et al., “Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy,”Nat. Genet., May 2000; 25(1):105-9.
Koob et al., “An untranslated CTG expression causes a novel form of spinocerebellar ataxia (SCA8),”Nat. Genet., Apr. 1999; 21(4):379-84.
Korade-Mirnics, “Myotonic dystrophy: molecular windows on a complex etiology,”Nucleic Acids Res., Jun. 1998; 26(6):1363-8.
Kruglyak et al., “Parametric and nonparametric linkage analysis: a unified multipoint approach,”Am. J. Hum. Genet., Jun. 1996; 58(6):1347-63.
Lathrop et al., “Strategies for multilocus linkage analysis in humans,”Proc. Natl. Acad. Sci. USA, 1984; 81(11):3443-6.
Liquori et al., “Myotonic dystrophy type 2 (DM2) Caused by a CCTG Expansion in Intron 1 ofZNF9,”Science, 2001; 293(5531):864-7.
Liquori et al., “Science—Liquori et al. 293(5531): 864 Data Supplement—Supplemental Data,” [online]. Available online Aug. 3, 2001. [retrieved on Sep. 12, 2002]. Retrieved from the Internet: <http://www.sciencemag.org/cgi/content/full/293/5531/864/DC1>.
López de Munain et al., “CTG trinucleotide repeat variability in identical twins with myotonic dystrophy,”Ann. Neurol., Mar. 1994; 35(3):374-5.
Lu et al., “Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy,”Hum. Mol. Genet., 1999; 8(1):53-60.
Mahadevan et al., “Myotonic dystrophy mutation: an unstable CTG repeat in the 3′ untranslated region of the gene,”Science, Mar. 6, 1992; 255(5049):1253-5.
Mankodi et al., “Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat,”Science, Sep. 8, 2000; 289(5485):1769-73.
Matsuura et al., “Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10,”Nat. Genet., Oct. 2000; 26(2):191-4.
Matsuura et al., “Polymerase chain reaction amplification of expanded ATTCT repeat in spinocerebellar ataxia type 10,”Ann. Neurol., Feb. 2002; 51(2):271-2.
McPherson et al., “A physical map of the human genome,”Nature, Feb. 15, 2001; 409(6822):934-41.
Miller et al., “Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy,”EMBO J., 2000; 19(17):4439-48.
Moutou et al., “Transition from premutation to full mutation in fragile X syndrome is likely to be prezygotic,”Hum. Mol. Genet., 1997; 6(7):971-9.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank Locus AC022944, Accession No. AC022944, “Homo sapienschromosome 3 clone RP11-814L21 map 3, Sequencing in Progress, 81 unordered pieces,” [online]. Bethesda, MD [retrieved on Jun. 21, 2001]. Retrieved from the Internet: <URL: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=7139791&dopt=GenBank>; 75 pages.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank LocusAC022993, Accession No. AC022993, “Homo sapienschromosome 3 clone RP11-72304 map 3, Working Draft Sequence, 14 unordered pieces.” [online]. Bethesda, MD [retrieved on Aug. 20, 2002]. Retrieved from the Internet: <URL: www.ncbi.nlm.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=10046450&dopt=GenBank>; 53 pgs.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank LocusAC023598, Accession No. AC023598, “Homo sapienschromosome 3 clone RP11-221E20, Working Draft Sequence, 3 unordered pieces.” [online]. Bethesda, MD [retrieved on Aug. 20, 2002]. Retrieved from the Internet: <URL: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list—uids=21700434&dopt=GenBank>; 56 pgs.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank LocusAF388525, Accession No. AF388525, “Homo sapiens ZNF9 gene, intron 1 and CL3N58 repeat region.” [online]. Bethesda, MD [retrieved on Aug. 20, 20
Day John W.
Liquori Christina
Ranum Laura P. W.
Mueting Raasch & Gebhardt, P.A.
Regents of the University of Minnesota
Strzelecka Teresa E
Wilder Cynthia
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